abhd2b abhydrolase domain containing 2, acylglycerol lipase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abhd2bprovided by ZNC
Official Full Name: abhydrolase domain containing 2, acylglycerol lipase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061027-74
See related: Ensembl:ENSDARG00000045804 AllianceGenome:ZFIN:ZDB-GENE-061027-74
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153750
Summary: Predicted to enable carboxylic ester hydrolase activity; hormone binding activity; and nuclear steroid receptor activity. Predicted to be involved in several processes, including medium-chain fatty acid metabolic process; response to progesterone; and sperm capacitation. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in plasma membrane. Predicted to be active in sperm flagellum and sperm plasma membrane. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (19120524..19139221, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (19022578..19041310, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylesterase activity	IEA Inferred from Electronic Annotation more info
enables acetylesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear steroid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in medium-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to progesterone	ISS Inferred from Sequence or Structural Similarity more info
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: monoacylglycerol lipase ABHD2

Names: 2-arachidonoylglycerol hydrolase; abhydrolase domain containing 2b; abhydrolase domain-containing protein 2-B; acetylesterase; monoacylglycerol lipase ABHD2-B; triacylglycerol lipase

NP_001073145.1

EC 3.1.1.23

EC 3.1.1.6

EC 3.1.1.79

XP_005163074.1

EC 3.1.1.23

EC 3.1.1.6

EC 3.1.1.79

XP_009296178.1

EC 3.1.1.23

EC 3.1.1.6

EC 3.1.1.79

XP_068073485.1

EC 3.1.1.23

EC 3.1.1.6

EC 3.1.1.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.