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aqp1a.2 aquaporin 1a (Colton blood group), tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 559284, updated on 9-Dec-2024

Summary

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Official Symbol
aqp1a.2provided by ZNC
Official Full Name
aquaporin 1a (Colton blood group), tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-100409-1
See related
Ensembl:ENSDARG00000091027 AllianceGenome:ZFIN:ZDB-GENE-100409-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables water transmembrane transporter activity. Acts upstream of or within transmembrane transport and water transport. Predicted to be located in membrane. Is expressed in brain; ovary; and testis. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See aqp1a.2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2761873..2770591)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (2919983..2928456)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 13 Neighboring gene SERPINE1 mRNA binding protein 1b Neighboring gene aquaporin 1a (Colton blood group), tandem duplicate 1 Neighboring gene THO complex 1 Neighboring gene ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a zebrafish homologue of human AQP1: a bifunctional water and gas channel. Chen LM, et al. Am J Physiol Regul Integr Comp Physiol, 2010 Nov. PMID 20739606, Free PMC Article
  2. Structural and functional divergence of two fish aquaporin-1 water channels following teleost-specific gene duplication. Tingaud-Sequeira A, et al. BMC Evol Biol, 2008 Sep 23. PMID 18811940, Free PMC Article
  3. Dual neofunctionalization of a rapidly evolving aquaporin-1 paralog resulted in constrained and relaxed traits controlling channel function during meiosis resumption in teleosts. Zapater C, et al. Mol Biol Evol, 2011 Nov. PMID 21653921
  4. Transcriptomic Responses of Bisphenol S Predict Involvement of Immune Function in the Cardiotoxicity of Early Life-Stage Zebrafish (Danio rerio). Qiu W, et al. Environ Sci Technol, 2020 Mar 3. PMID 31888327
  5. Variation of DNA Methylome of Zebrafish Cells under Cold Pressure. Han B, et al. PLoS One, 2016. PMID 27494266, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ammonium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbon dioxide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbon dioxide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hyperosmotic response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in renal water transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aquaporin-1a.2
Names
Aqp1ab
Aqp1b
aquaporin 1a, tandem duplicate 2
aquaporin 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135682.1 → NP_001129154.1  aquaporin-1a.2

    See identical proteins and their annotated locations for NP_001129154.1

    Status: PROVISIONAL

    Source sequence(s)
    EU327345
    UniProtKB/TrEMBL
    B6CMI5
    Related
    ENSDARP00000110131.1, ENSDART00000127523.2
    Conserved Domains (1) summary
    pfam00230
    Location:4 → 221
    MIP; Major intrinsic protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    2761873..2770591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480566.2 → XP_021336241.1  aquaporin-1a.2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QJM6, F1QQB8
    Conserved Domains (1) summary
    pfam00230
    Location:4 → 221
    MIP; Major intrinsic protein

  2. XM_009299086.4 → XP_009297361.1  aquaporin-1a.2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQ72
    Conserved Domains (1) summary
    pfam00230
    Location:4 → 221
    MIP; Major intrinsic protein
Nucleotide Protein Strain
Heading Accession and Version

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