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myofl myoferlin like [ Danio rerio (zebrafish) ]

Gene ID: 559066, updated on 9-Dec-2024

Summary

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Official Symbol
myoflprovided by ZNC
Official Full Name
myoferlin likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-111116-2
See related
Ensembl:ENSDARG00000017128 AllianceGenome:ZFIN:ZDB-GENE-111116-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable metal ion binding activity. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in hereditary angioedema. Orthologous to human MYOF (myoferlin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See myofl in Genome Data Viewer
Location:
chromosome: 13
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (29238782..29289246)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (29108292..29158796)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member pge Neighboring gene unc-5 netrin receptor B Neighboring gene poly (ADP-ribose) glycohydrolase a Neighboring gene oxoglutarate dehydrogenase L Neighboring gene zgc:153142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
  2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myoferlin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    29238782..29289246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_682373.10 → XP_687465.5  myoferlin

    UniProtKB/TrEMBL
    A0A8N7T5L8
    Related
    ENSDARP00000005170.8, ENSDART00000026000.9
    Conserved Domains (12) summary
    cd04011
    Location:202 → 311
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1131 → 1265
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:365 → 541
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1543 → 1666
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1779 → 1910
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:862 → 920
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:775 → 847
    FerB; FerB (NUC096) domain
    pfam08151
    Location:310 → 359
    FerI; FerI (NUC094) domain
    pfam08165
    Location:685 → 743
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1924 → 2038
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1294 → 1396
    C2; C2 domain
Nucleotide Protein Strain
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