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ulk1b unc-51 like autophagy activating kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 558848, updated on 26-Jan-2025

Summary

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Official Symbol
ulk1bprovided by ZNC
Official Full Name
unc-51 like autophagy activating kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-071203-2
See related
Ensembl:ENSDARG00000074481 AllianceGenome:ZFIN:ZDB-GENE-071203-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ulk1; si:dkey-11o18.7
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including axon extension; macroautophagy; and negative regulation of collateral sprouting. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Is expressed in liver. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ulk1b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (14835251..14878244, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (14740904..14781524, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909433 Neighboring gene nucleolar complex associated 4 homolog Neighboring gene pseudouridine synthase 1 Neighboring gene matrix metallopeptidase 17a Neighboring gene splicing factor SWAP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Metformin accelerates zebrafish heart regeneration by inducing autophagy. Xie F, et al. NPJ Regen Med, 2021 Oct 8. PMID 34625572, Free PMC Article
  2. Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos. Geng FS, et al. MicroPubl Biol, 2020 Dec 8. PMID 33313487, Free PMC Article
  3. Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter. Sun C, et al. Front Mol Neurosci, 2022. PMID 35754707, Free PMC Article
  4. Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. He C, et al. Autophagy, 2009 May. PMID 19221467, Free PMC Article
  5. Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish. Xin S, et al. Mar Drugs, 2024 Mar 27. PMID 38667765, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase ULK2; serine/threonine-protein kinase ULK1
Names
unc-51 like autophagy activating kinase 1b
unc-51-like kinase 1
unc-51-like kinase 1b
XP_002665971.2
XP_005161178.1
XP_021324714.1
XP_068072121.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    14835251..14878244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161121.5 → XP_005161178.1  serine/threonine-protein kinase ULK1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B823
    Conserved Domains (3) summary
    smart00220
    Location:9 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12063
    Location:795 → 1006
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:6 → 272
    PKc_like; Protein Kinases, catalytic domain

  2. XM_002665925.7 → XP_002665971.2  serine/threonine-protein kinase ULK1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1RRT1, E9QIB7
    Related
    ENSDARP00000113763.2, ENSDART00000131237.3
    Conserved Domains (3) summary
    smart00220
    Location:9 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12063
    Location:796 → 1007
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:6 → 272
    PKc_like; Protein Kinases, catalytic domain

  3. XM_021469039.2 → XP_021324714.1  serine/threonine-protein kinase ULK1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PIT5
    Conserved Domains (2) summary
    pfam12063
    Location:795 → 1008
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:6 → 272
    PKc_like; Protein Kinases, catalytic domain

  4. XM_068216020.1 → XP_068072121.1  serine/threonine-protein kinase ULK1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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