adarb1b adenosine deaminase RNA specific B1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adarb1bprovided by ZNC
Official Full Name: adenosine deaminase RNA specific B1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030219-15
See related: Ensembl:ENSDARG00000003544 AllianceGenome:ZFIN:ZDB-GENE-030219-15
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adarb1; id:ibd3153; si:ch211-268b13.2
Summary: Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to be active in cytoplasm and nucleolus. Is expressed in blood island; blood vessel; immature eye; and nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (45227104..45542813)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (45426122..45741714)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fi33e10.y1 (e-PCR)
- UniSTS:197314

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: double-stranded RNA-specific editase 1

Names: adenosine deaminase, RNA-specific, B1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

45227104..45542813

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_682018.10 → XP_687110.6 double-stranded RNA-specific editase 1 isoform X2

UniProtKB/TrEMBL

A0A8N7T714, E9QJK5

Related

ENSDARP00000154696.1, ENSDART00000185579.1

Conserved Domains (3) summary

smart00358
Location:76 → 138

DSRM; Double-stranded RNA binding motif

smart00552
Location:320 → 696

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd00048
Location:233 → 278

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
XM_021479019.2 → XP_021334694.1 double-stranded RNA-specific editase 1 isoform X2

UniProtKB/TrEMBL

A0A8N7T714, E9QJK5

Related

ENSDARP00000146245.1, ENSDART00000193087.1

Conserved Domains (3) summary

smart00358
Location:76 → 138

DSRM; Double-stranded RNA binding motif

smart00552
Location:320 → 696

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd00048
Location:233 → 278

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
XM_021479018.2 → XP_021334693.1 double-stranded RNA-specific editase 1 isoform X1

UniProtKB/TrEMBL

A0A8M9Q590

Conserved Domains (3) summary

smart00358
Location:127 → 189

DSRM; Double-stranded RNA binding motif

smart00552
Location:371 → 747

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd00048
Location:284 → 329

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...