nrxn2a neurexin 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrxn2aprovided by ZNC
Official Full Name: neurexin 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070206-5
See related: Ensembl:ENSDARG00000061454 AllianceGenome:ZFIN:ZDB-GENE-070206-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within axon extension involved in axon guidance; chemical synaptic transmission; and motor neuron axon guidance. Predicted to be located in membrane. Is expressed in nervous system and spinal cord neural tube. Orthologous to human NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (27635485..28340997, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (27598788..28304660, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To confirm the function of nrxn2a, rescue experiments were performed using beta-nrxn2a mRNA microinjection. Pb exposure increased apoptosis and altered locomotor behavior in zebrafish larvae. Quantitative PCR showed that among several synaptic adhesion molecules, only nrxn2a were affected by Pb exposure.
Title: Role of neurexin2a in lead-induced locomotor defect in developing zebrafish.
SMN deficiency affects splicing and abundance of nrxn2a. This may explain the pre-synaptic defects at neuromuscular endplates in SMA pathophysiology.
Title: SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.

Submit: New GeneRIF Correction

General gene information

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Markers

G41695 (e-PCR)
- UniSTS:22068

fj61b03.x1 (e-PCR)
- UniSTS:204632

z51357 (e-PCR), detects polymorphism
- UniSTS:238446

OMY6034INRA (e-PCR)
- UniSTS:529028

G38941 (e-PCR)
- UniSTS:32407

fj33b05.x1 (e-PCR)
- UniSTS:199098

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurexin-2-beta

Names: nrxn2aa; nrxn2ab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079970.1 → NP_001073439.1 neurexin-2-beta precursor

See identical proteins and their annotated locations for NP_001073439.1

Status: PROVISIONAL

Source sequence(s)

DQ641428

UniProtKB/TrEMBL

A1XQX4

Related

ENSDARP00000119607.1, ENSDART00000141629.3

Conserved Domains (6) summary

smart00282
Location:304 → 450

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:485 → 650

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam02210
Location:935 → 1063

Laminin_G_2; Laminin G domain

pfam06484
Location:1435 → 1569

Ten_N; Teneurin Intracellular Region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

27635485..28340997 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068215893.1 → XP_068071994.1 neurexin-2-beta isoform X10
XM_021468853.2 → XP_021324528.1 neurexin-2-beta isoform X8

UniProtKB/TrEMBL

A0A8M9PCQ0

Conserved Domains (7) summary

smart00282
Location:281 → 428

LamG; Laminin G domain

cd00054
Location:658 → 691

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:463 → 628

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1569 → 1619

Syndecan; Syndecan domain

pfam02210
Location:910 → 1038

Laminin_G_2; Laminin G domain

pfam06484
Location:1410 → 1544

Ten_N; Teneurin Intracellular Region
XM_021468858.2 → XP_021324533.1 neurexin-2-beta isoform X17

UniProtKB/TrEMBL

A0A8M9PCQ2

Conserved Domains (6) summary

smart00282
Location:304 → 435

LamG; Laminin G domain

cd00054
Location:665 → 698

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:470 → 635

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1377 → 1427

Syndecan; Syndecan domain

pfam02210
Location:908 → 1036

Laminin_G_2; Laminin G domain
XM_068215892.1 → XP_068071993.1 neurexin-2-beta isoform X9
XM_009295478.4 → XP_009293753.1 neurexin-2-beta isoform X14

UniProtKB/TrEMBL

A0A8M3ALL4

Conserved Domains (6) summary

smart00282
Location:304 → 435

LamG; Laminin G domain

cd00054
Location:665 → 698

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:470 → 635

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1416 → 1466

Syndecan; Syndecan domain

pfam02210
Location:917 → 1045

Laminin_G_2; Laminin G domain
XM_009295477.4 → XP_009293752.1 neurexin-2-beta isoform X7

UniProtKB/TrEMBL

A0A8M3AU05

Conserved Domains (7) summary

smart00282
Location:304 → 435

LamG; Laminin G domain

cd00054
Location:665 → 698

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:470 → 635

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1576 → 1626

Syndecan; Syndecan domain

pfam02210
Location:917 → 1045

Laminin_G_2; Laminin G domain

pfam06484
Location:1417 → 1551

Ten_N; Teneurin Intracellular Region
XM_068215891.1 → XP_068071992.1 neurexin-2-beta isoform X6
XM_009295476.4 → XP_009293751.1 neurexin-2-beta isoform X3

UniProtKB/TrEMBL

A0A8M3AWZ3

Conserved Domains (7) summary

smart00282
Location:304 → 443

LamG; Laminin G domain

cd00054
Location:673 → 706

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:478 → 643

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1584 → 1634

Syndecan; Syndecan domain

pfam02210
Location:925 → 1053

Laminin_G_2; Laminin G domain

pfam06484
Location:1425 → 1559

Ten_N; Teneurin Intracellular Region
XM_068215895.1 → XP_068071996.1 neurexin-2-beta isoform X16

UniProtKB/TrEMBL

A0A8M9P3C5
XM_068215890.1 → XP_068071991.1 neurexin-2-beta isoform X5

UniProtKB/TrEMBL

A0A8M9P3C3
XM_068215894.1 → XP_068071995.1 neurexin-2-beta isoform X13
XM_021468850.2 → XP_021324525.1 neurexin-2-beta isoform X2

UniProtKB/TrEMBL

A0A8M9PTW7

Conserved Domains (7) summary

smart00282
Location:304 → 450

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:485 → 650

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1591 → 1641

Syndecan; Syndecan domain

pfam02210
Location:932 → 1060

Laminin_G_2; Laminin G domain

pfam06484
Location:1432 → 1566

Ten_N; Teneurin Intracellular Region
XM_021468851.2 → XP_021324526.1 neurexin-2-beta isoform X4

UniProtKB/TrEMBL

A0A8M9PQH6

Conserved Domains (7) summary

smart00282
Location:304 → 451

LamG; Laminin G domain

cd00054
Location:681 → 714

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:486 → 651

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1583 → 1633

Syndecan; Syndecan domain

pfam02210
Location:924 → 1052

Laminin_G_2; Laminin G domain

pfam06484
Location:1424 → 1558

Ten_N; Teneurin Intracellular Region
XM_021468856.2 → XP_021324531.1 neurexin-2-beta isoform X15

UniProtKB/TrEMBL

A0A8M9PQI0

Conserved Domains (6) summary

smart00282
Location:304 → 451

LamG; Laminin G domain

cd00054
Location:681 → 714

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:486 → 651

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1402 → 1452

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain
XM_021468854.2 → XP_021324529.1 neurexin-2-beta isoform X11

UniProtKB/TrEMBL

A0A8M9PIB5

Conserved Domains (7) summary

smart00282
Location:304 → 451

LamG; Laminin G domain

cd00054
Location:681 → 714

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:486 → 651

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1562 → 1612

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain

pfam06484
Location:1403 → 1537

Ten_N; Teneurin Intracellular Region
XM_021468855.2 → XP_021324530.1 neurexin-2-beta isoform X12

UniProtKB/TrEMBL

A0A8M9PTX2

Conserved Domains (6) summary

smart00282
Location:304 → 451

LamG; Laminin G domain

cd00054
Location:681 → 714

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:486 → 651

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1432 → 1482

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain
XM_021468849.2 → XP_021324524.1 neurexin-2-beta isoform X1

UniProtKB/TrEMBL

A0A8M9PIB2

Conserved Domains (7) summary

smart00282
Location:304 → 451

LamG; Laminin G domain

cd00054
Location:681 → 714

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:486 → 651

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:204 → 236

EGF; EGF-like domain

pfam01034
Location:1592 → 1642

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain

pfam06484
Location:1433 → 1567

Ten_N; Teneurin Intracellular Region
XM_021468859.2 → XP_021324534.1 neurexin-2-beta isoform X20

UniProtKB/TrEMBL

A0A8M9PIB8

Conserved Domains (2) summary

pfam01034
Location:382 → 432

Syndecan; Syndecan domain

pfam02210
Location:137 → 255

Laminin_G_2; Laminin G domain
XM_005161353.5 → XP_005161410.1 neurexin-2-beta isoform X19

UniProtKB/TrEMBL

A0A8M2B8E6

Conserved Domains (2) summary

cd00110
Location:106 → 284

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:412 → 462

Syndecan; Syndecan domain
XM_009295479.4 → XP_009293754.1 neurexin-2-beta isoform X18

UniProtKB/TrEMBL

A0A8M3AMB4, A0A8M3B4U6, B7ZCV1

Related

ENSDARP00000118463.1, ENSDART00000132583.3

Conserved Domains (3) summary

pfam01034
Location:572 → 622

Syndecan; Syndecan domain

pfam02210
Location:137 → 285

Laminin_G_2; Laminin G domain

pfam06484
Location:413 → 547

Ten_N; Teneurin Intracellular Region