xpr1b xenotropic and polytropic retrovirus receptor 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: xpr1bprovided by ZNC
Official Full Name: xenotropic and polytropic retrovirus receptor 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-266
See related: Ensembl:ENSDARG00000029671 AllianceGenome:ZFIN:ZDB-GENE-060503-266
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: xpr1; si:dkey-60b12.7
Summary: Enables efflux transmembrane transporter activity and phosphate transmembrane transporter activity. Involved in phosphate ion transmembrane transport. Acts upstream of or within microglia differentiation and skeletal system development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (6999369..7057330)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (7127763..7185724)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The xpr1b mutants display no gross developmental defects that may arise from phosphate imbalance.
Title: The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages.

Submit: New GeneRIF Correction

General gene information

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Markers

fi71h10.x1 (e-PCR)
- UniSTS:197908

fj03d09.x1 (e-PCR)
- UniSTS:198319

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables efflux transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol hexakisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol hexakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to phosphate starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular phosphate ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microglia differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphate ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: xenotropic and polytropic retrovirus receptor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126390.1 → NP_001119862.1 xenotropic and polytropic retrovirus receptor 1 homolog

See identical proteins and their annotated locations for NP_001119862.1

Status: PROVISIONAL

Source sequence(s)

AL953893

UniProtKB/Swiss-Prot

A8DZH4

Related

ENSDARP00000050596.7, ENSDART00000050597.8

Conserved Domains (3) summary

cd14477
Location:2 → 164

SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins

pfam03105
Location:3 → 172

SPX; SPX domain

pfam03124
Location:289 → 616

EXS; EXS family