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usp32 ubiquitin specific peptidase 32 [ Danio rerio (zebrafish) ]

Gene ID: 557981, updated on 9-Dec-2024

Summary

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Official Symbol
usp32provided by ZNC
Official Full Name
ubiquitin specific peptidase 32provided by ZNC
Primary source
ZFIN:ZDB-GENE-100210-5
See related
Ensembl:ENSDARG00000061895 AllianceGenome:ZFIN:ZDB-GENE-100210-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fe14d02
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within protein deubiquitination. Predicted to be active in Golgi apparatus. Orthologous to human USP32 (ubiquitin specific peptidase 32). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See usp32 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23816945..23908741, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23883827..23973499, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch211-167j9.5 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) Neighboring gene transmembrane protein 97 Neighboring gene si:ch1073-145m9.1 Neighboring gene amyloid beta precursor protein (cytoplasmic tail) binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. Kuil LE, et al. PLoS Genet, 2021 Aug. PMID 34358225, Free PMC Article
  2. Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Chen W, et al. Mar Drugs, 2019 Jul 20. PMID 31330852, Free PMC Article
  3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 32
XP_068069823.1
XP_068069824.1
XP_068069825.1
XP_686236.6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    23816945..23908741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213723.1 → XP_068069824.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B4G2

  2. XM_681144.10 → XP_686236.6  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B4G2, A0A8N7T783, E7FCR5
    Related
    ENSDARP00000083241.4, ENSDART00000088808.6
    Conserved Domains (7) summary
    COG5560
    Location:521 → 1546
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:237 → 293
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:1220 → 1546
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:519 → 586
    DUSP; DUSP domain
    pfam13499
    Location:236 → 293
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:623 → 710
    Ubiquitin_3; Ubiquitin-like domain
    cl08302
    Location:270 → 338
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_068213722.1 → XP_068069823.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4G2

  4. XM_068213724.1 → XP_068069825.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

    UniProtKB/TrEMBL
    A0A8M3ASU9
Nucleotide Protein Strain
Heading Accession and Version

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