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TXLNG taxilin gamma [ Homo sapiens (human) ]

Gene ID: 55787, updated on 27-Nov-2024

Summary

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Official Symbol
TXLNGprovided by HGNC
Official Full Name
taxilin gammaprovided by HGNC
Primary source
HGNC:HGNC:18578
See related
Ensembl:ENSG00000086712 MIM:300677; AllianceGenome:HGNC:18578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELRG; FIAT; LSR5; TXLNGX; CXorf15
Summary
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in adrenal (RPKM 8.1), fat (RPKM 7.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See TXLNG in Genome Data Viewer
Location:
Xp22.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (16786466..16844519)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (16368976..16427050)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16804589..16862642)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:16789601-16790126 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:16790127-16790652 Neighboring gene RNA, U7 small nuclear 56 pseudogene Neighboring gene uncharacterized LOC124905250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29455 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:16804156-16804888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20680 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:16806931-16807431 Neighboring gene ribosomal protein L12 pseudogene 49 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:16844989-16845504 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:16846635-16847134 Neighboring gene uncharacterized LOC124905251 Neighboring gene RB binding protein 7, chromatin remodeling factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20682 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:16888501-16889179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29457 Neighboring gene RNA, U4 small nuclear 6, pseudogene Neighboring gene SLC35C2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin modulates bone mass accrual. Yu VW, et al. Ann N Y Acad Sci, 2006 Apr. PMID 16831913
  2. γ-Taxilin temporally regulates centrosome disjunction in a Nek2A-dependent manner. Makiyama T, et al. Exp Cell Res, 2018 Jan 15. PMID 29225051
  3. TXLNG improves insulin resistance in obese subjects in vitro and in vivo by inhibiting ATF4 transcriptional activity. Tao J, et al. Mol Cell Endocrinol, 2023 Jun 1. PMID 37028586
  4. Over-expression and siRNA of a novel environmental lipopolysaccharide-responding gene on the cell cycle of the human hepatoma-derived cell line HepG2. Du K, et al. Toxicology, 2008 Jan 20. PMID 18068885
  5. Combinatorial control of ATF4-dependent gene transcription in osteoblasts. St-Arnaud R, et al. Ann N Y Acad Sci, 2011 Nov. PMID 22082360, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TXLNG improves insulin resistance in obese subjects in vitro and in vivo by inhibiting ATF4 transcriptional activity.
    Title: TXLNG improves insulin resistance in obese subjects in vitro and in vivo by inhibiting ATF4 transcriptional activity.
  2. alpha-/gamma-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
    Title: α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
  3. Taken together with the result that gamma-taxilin protein expression levels were decreased at the onset of mitosis, we propose that gamma-taxilin participates in Nek2A-mediated centrosome disjunction as a negative regulator through its interaction with Nek2A.
    Title: γ-Taxilin temporally regulates centrosome disjunction in a Nek2A-dependent manner.
  4. [review] First evidence of a functional interaction between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).
    Title: Combinatorial control of ATF4-dependent gene transcription in osteoblasts.
  5. evaluation of the effects of a novel environmental lipopolysaccharide-responding (Elrg) gene on the regulation of proliferation and cell cycle of the hepatoma-derived cell line, HepG2
    Title: Over-expression and siRNA of a novel environmental lipopolysaccharide-responding gene on the cell cycle of the human hepatoma-derived cell line HepG2.
  6. identification of isoforms of taxilin; interaction with syntaxin; tissue distribution [beta-taxilin, gamma-taxilin].
    Title: Identification and characterization of taxilin isoforms.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11209, FLJ33481, MGC126621, MGC126625

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gamma-taxilin
Names
environmental LPS-responding
environmental lipopolysaccharide-responding gene protein
factor inhibiting ATF4-mediated transcription
factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription
lipopolysaccharide specific response-5 protein
lipopolysaccharide-specific response protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016267.1 RefSeqGene

    Range
    5035..63088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168683.2 → NP_001162154.1  gamma-taxilin isoform 2

    See identical proteins and their annotated locations for NP_001162154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA731379, AF143740, AK123142, AW197225, AY739713, DA516680, DB098819
    Consensus CDS
    CCDS55373.1
    UniProtKB/Swiss-Prot
    Q9NUQ3
    Related
    ENSP00000381222.4, ENST00000398155.4
    Conserved Domains (2) summary
    pfam09728
    Location:35 → 313
    Taxilin; Myosin-like coiled-coil protein
    cl19219
    Location:246 → 331
    DUF342; Protein of unknown function (DUF342)

  2. NM_018360.3 → NP_060830.2  gamma-taxilin isoform 1

    See identical proteins and their annotated locations for NP_060830.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA731379, AF143740, AK123142, AW197225, BC101576, DA516680
    Consensus CDS
    CCDS14178.1
    UniProtKB/Swiss-Prot
    Q2KQ75, Q5JNZ7, Q9NUQ3, Q9P0X1
    Related
    ENSP00000369465.5, ENST00000380122.10
    Conserved Domains (2) summary
    pfam09728
    Location:138 → 445
    Taxilin; Myosin-like coiled-coil protein
    cl19219
    Location:378 → 463
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    16786466..16844519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442249.1 → XP_047298205.1  gamma-taxilin isoform X2

  2. XM_024452400.2 → XP_024308168.1  gamma-taxilin isoform X1

    Conserved Domains (1) summary
    pfam09728
    Location:98 → 405
    Taxilin; Myosin-like coiled-coil protein

  3. XM_017029631.2 → XP_016885120.1  gamma-taxilin isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    16368976..16427050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327383.1 → XP_054183358.1  gamma-taxilin isoform X2

  2. XM_054327382.1 → XP_054183357.1  gamma-taxilin isoform X1

  3. XM_054327384.1 → XP_054183359.1  gamma-taxilin isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUQ3.2 GenPept UniProtKB/Swiss-Prot:Q9NUQ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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