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znf451 zinc finger protein 451 [ Danio rerio (zebrafish) ]

Gene ID: 557758, updated on 9-Dec-2024

Summary

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Official Symbol
znf451provided by ZNC
Official Full Name
zinc finger protein 451provided by ZNC
Primary source
ZFIN:ZDB-GENE-081107-14
See related
Ensembl:ENSDARG00000076939 AllianceGenome:ZFIN:ZDB-GENE-081107-14
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-165e15.5
Summary
Predicted to enable ligase activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See znf451 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (1409781..1427255, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (1279495..1297003, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene RAB23, member RAS oncogene family Neighboring gene BCL2 associated athanogene 2 Neighboring gene dystonin Neighboring gene uncharacterized LOC137487351 Neighboring gene zmp:0000000760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of bovine A20 gene: Expression mediated by NF-κB pathway in MDBK cells infected with bovine viral diarrhea virus-1. Fredericksen F, et al. Gene, 2016 May 1. PMID 26809100
  2. Melanoma genome evolution across species. Kansler ER, et al. BMC Genomics, 2017 Feb 7. PMID 28173755, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase ZNF451; zinc finger protein 451

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    1409781..1427255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358909.3 → XP_017214398.1  E3 SUMO-protein ligase ZNF451 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z1V8, A0A8M9PY94

  2. XM_001923135.7 → XP_001923170.1  E3 SUMO-protein ligase ZNF451 isoform X1

    See identical proteins and their annotated locations for XP_001923170.1

    UniProtKB/TrEMBL
    A0A8M1QHV0, A0A8M9PY94, B8A455
    Related
    ENSDARP00000120051.1, ENSDART00000145867.3
    Conserved Domains (2) summary
    pfam12756
    Location:188 → 252
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    cl26511
    Location:759 → 915
    Neuromodulin_N; Gap junction protein N-terminal region

RNA

  1. XR_011005870.1 RNA Sequence

  2. XR_222069.5 RNA Sequence

  3. XR_011005872.1 RNA Sequence

  4. XR_011005871.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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