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prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 [ Danio rerio (zebrafish) ]

Gene ID: 557288, updated on 9-Dec-2024

Summary

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Official Symbol
prex2provided by ZNC
Official Full Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-091113-37
See related
Ensembl:ENSDARG00000071692 AllianceGenome:ZFIN:ZDB-GENE-091113-37
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-278g15.1
Summary
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of signaling. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See prex2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (18948511..19207057)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (18804031..19062640)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) Neighboring gene si:dkey-4m13.3 Neighboring gene carboxypeptidase A6 Neighboring gene zgc:162928 Neighboring gene sulfatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. Dalton LE, et al. J Invest Dermatol, 2013 Jun. PMID 23337888
  2. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    18948511..19207057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001923322.6 → XP_001923357.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

    UniProtKB/TrEMBL
    A0A8M1QHV7, E7F2H9
    Related
    ENSDARP00000096964.4, ENSDART00000106186.6
    Conserved Domains (6) summary
    cd00992
    Location:676 → 743
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04440
    Location:473 → 565
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:217 → 363
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:247 → 355
    PH; PH domain
    pfam00621
    Location:27 → 212
    RhoGEF; RhoGEF domain
    cl02442
    Location:381 → 461
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
Nucleotide Protein
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