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slc26a2 solute carrier family 26 member 2 [ Danio rerio (zebrafish) ]

Gene ID: 557046, updated on 9-Dec-2024

Summary

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Official Symbol
slc26a2provided by ZNC
Official Full Name
solute carrier family 26 member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030717-3
See related
Ensembl:ENSDARG00000011618 AllianceGenome:ZFIN:ZDB-GENE-030717-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Acts upstream of or within several processes, including inner ear development; sensory perception of sound; and swimming behavior. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in lateral line primordium; midbrain; otic vesicle; pectoral fin bud; and pronephric duct. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See slc26a2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (25438200..25452295, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (25143226..25155077, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:rp71-1d10.8 Neighboring gene 5-hydroxytryptamine receptor 4 Neighboring gene microRNA 458 Neighboring gene shootin 3 Neighboring gene THO complex 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects. Weber T, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12782792, Free PMC Article
  2. The involvement of SLC26 anion transporters in chloride uptake in zebrafish (Danio rerio) larvae. Bayaa M, et al. J Exp Biol, 2009 Oct. PMID 19801433
  3. Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. Liu F, et al. PLoS One, 2015. PMID 26375458, Free PMC Article
  4. Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system. Urasaki A, et al. Sci Rep, 2019 Aug 21. PMID 31434971, Free PMC Article
  5. The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. Wingert RA, et al. PLoS Genet, 2007 Oct. PMID 17953490, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment
    Title: Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otolith morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sulfate transporter
Names
solute carrier family 26 (anion exchanger), member 2
solute carrier family 26 (sulfate transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    25438200..25452295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_680022.6 → XP_685114.1  sulfate transporter

    See identical proteins and their annotated locations for XP_685114.1

    UniProtKB/TrEMBL
    A0A8N7UQQ2, E7F9I7
    Related
    ENSDARP00000124111.1, ENSDART00000148652.3
    Conserved Domains (2) summary
    cd07042
    Location:531 → 665
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:63 → 681
    sulP; high affinity sulphate transporter 1

  2. XM_005173160.5 → XP_005173217.1  sulfate transporter

    See identical proteins and their annotated locations for XP_005173217.1

    UniProtKB/TrEMBL
    A0A8N7UQQ2, E7F9I7
    Conserved Domains (2) summary
    cd07042
    Location:531 → 665
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:63 → 681
    sulP; high affinity sulphate transporter 1
Nucleotide Protein Strain
Heading Accession and Version

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