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adcy1a adenylate cyclase 1a [ Danio rerio (zebrafish) ]

Gene ID: 557026, updated on 9-Dec-2024

Summary

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Official Symbol
adcy1aprovided by ZNC
Official Full Name
adenylate cyclase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-302
See related
Ensembl:ENSDARG00000069026 AllianceGenome:ZFIN:ZDB-GENE-070705-302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-162m2.1
Summary
Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and cAMP biosynthetic process. Predicted to act upstream of or within cyclic nucleotide biosynthetic process and intracellular signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See adcy1a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (6894886..7000225, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (6904939..7011184, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 1a Neighboring gene uncharacterized LOC108180199 Neighboring gene si:ch211-121a2.2 Neighboring gene sirtuin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish. Santos-Cortez RL, et al. Hum Mol Genet, 2014 Jun 15. PMID 24482543, Free PMC Article
  2. The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing. Xu H, et al. J Neurosci, 2010 May 26. PMID 20505109, Free PMC Article
  3. Ghrelin regulates hyperactivity-like behaviors via growth hormone signaling pathway in zebrafish (Danio rerio). Guan K, et al. Front Endocrinol (Lausanne), 2023. PMID 37065761, Free PMC Article
  4. Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Zhong Y, et al. Front Endocrinol (Lausanne), 2016. PMID 28149290, Free PMC Article
  5. Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. Yang S, et al. Int J Mol Sci, 2022 Jul 7. PMID 35886872, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate that ADCY1 has an evolutionarily conserved role in hearing.
    Title: Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenylate cyclase type 1
NP_001161821.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168349.1 → NP_001161821.1  adenylate cyclase type 1

    See identical proteins and their annotated locations for NP_001161821.1

    Status: PROVISIONAL

    Source sequence(s)
    GU169394
    UniProtKB/TrEMBL
    D1MIA2
    Related
    ENSDARP00000090870.4, ENSDART00000100098.5
    Conserved Domains (4) summary
    smart00044
    Location:251 → 446
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:852 → 1048
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:513 → 601
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:154 → 285
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    6894886..7000225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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