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stxbp5a syntaxin binding protein 5a (tomosyn) [ Danio rerio (zebrafish) ]

Gene ID: 556789, updated on 4-Jan-2025

Summary

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Official Symbol
stxbp5aprovided by ZNC
Official Full Name
syntaxin binding protein 5a (tomosyn)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041001-161
See related
Ensembl:ENSDARG00000002656 AllianceGenome:ZFIN:ZDB-GENE-041001-161
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-279m15.2
Summary
Predicted to act upstream of or within exocytosis. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See stxbp5a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (31748648..31905966, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (31845909..32003287, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488589 Neighboring gene uronyl 2-sulfotransferase a Neighboring gene SAM and SH3 domain containing 1a Neighboring gene uncharacterized LOC137488662 Neighboring gene androglobin Neighboring gene RAB32a, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish. Zhu H, et al. J Exp Zool B Mol Dev Evol, 2022 Jul. PMID 35226401
  2. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
syntaxin-binding protein 5a
Names
stxbp5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099981.2 → NP_001093451.1  syntaxin-binding protein 5a

    Status: PROVISIONAL

    Source sequence(s)
    BX649312, BX927258, CT573242
    UniProtKB/TrEMBL
    A0A8M1NDY6, A0A8M9PHB6, Q5RGD1
    Related
    ENSDARP00000114105.1, ENSDART00000142806.3
    Conserved Domains (5) summary
    COG2319
    Location:42 → 270
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1061 → 1121
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:272 → 379
    LLGL; LLGL2
    sd00039
    Location:57 → 90
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:57 → 275
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    31748648..31905966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294730.4 → XP_009293005.1  syntaxin-binding protein 5a isoform X3

    UniProtKB/TrEMBL
    A0A8M3ALK2, A0A8M9PHB6
    Conserved Domains (5) summary
    COG2319
    Location:42 → 270
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1028 → 1088
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:272 → 379
    LLGL; LLGL2
    sd00039
    Location:57 → 90
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:57 → 275
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_009294728.4 → XP_009293003.1  syntaxin-binding protein 5a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B457, A0A8M9PHB6
    Conserved Domains (5) summary
    COG2319
    Location:42 → 270
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1059 → 1119
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:272 → 379
    LLGL; LLGL2
    sd00039
    Location:57 → 90
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:57 → 275
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_009294727.4 → XP_009293002.1  syntaxin-binding protein 5a isoform X1

    UniProtKB/TrEMBL
    A0A8M3AKV9, A0A8M9PHB6
    Conserved Domains (5) summary
    COG2319
    Location:42 → 270
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1075 → 1135
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:272 → 379
    LLGL; LLGL2
    sd00039
    Location:57 → 90
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:57 → 275
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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