crkl v-crk avian sarcoma virus CT10 oncogene homolog-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crklprovided by ZNC
Official Full Name: v-crk avian sarcoma virus CT10 oncogene homolog-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2951
See related: Ensembl:ENSDARG00000028699 AllianceGenome:ZFIN:ZDB-GENE-040426-2951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63469; wu:fa55g05; wu:fj60e01
Summary: Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Acts upstream of or within myoblast fusion; pronephros morphogenesis; and retina layer formation. Predicted to be active in cytoplasm. Is expressed in nervous system; otic vesicle; and pronephros. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (18950575..18958079)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (18913939..18921443)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The adaptor proteins Crk and Crk-like (Crkl), with which Dock proteins are known to interact physically, are also required for myoblast fusion.
Title: A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.

Submit: New GeneRIF Correction

General gene information

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Markers

fa55g05.s1 (e-PCR)
- UniSTS:202537

fj60e01.x1 (e-PCR)
- UniSTS:199658

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in enzyme-linked receptor protein signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell motility	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: crk-like protein

Names: v-crk sarcoma virus CT10 oncogene homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213538.1 → NP_998703.1 crk-like protein

See identical proteins and their annotated locations for NP_998703.1

Status: PROVISIONAL

Source sequence(s)

BC056763

UniProtKB/TrEMBL

B7ZUZ0, Q6PH06

Related

ENSDARP00000037263.4, ENSDART00000036172.5

Conserved Domains (3) summary

cd09926
Location:6 → 106

SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK

cd11758
Location:127 → 181

SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

cl17036
Location:239 → 295

SH3; Src Homology 3 domain superfamily