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cfp complement factor properdin [ Danio rerio (zebrafish) ]

Gene ID: 556399, updated on 9-Dec-2024

Summary

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Official Symbol
cfpprovided by ZNC
Official Full Name
complement factor properdinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9247
See related
Ensembl:ENSDARG00000094451 AllianceGenome:ZFIN:ZDB-GENE-030131-9247
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fj10b08; ch:af064832; si:dkeyp-22b2.3
Summary
Acts upstream of or within immune response. Is expressed in several structures, including cardiovascular system; digestive system; eye; gonad; and neutrophil. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See cfp in Genome Data Viewer
Location:
chromosome: 8
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23672252..23684659, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23651013..23667293, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene si:ch73-237c6.1 Neighboring gene peroxisome proliferator-activated receptor delta b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression and functional analysis of properdin in zebrafish Danio rerio. Zhang Y, et al. Dev Comp Immunol, 2013 Jun. PMID 23416932
  2. Three isoforms of complement properdin factor P in trout: cloning, expression, gene organization and constrained modeling. Chondrou M, et al. Dev Comp Immunol, 2008. PMID 18638502
  3. A comparison of behavioral and reproductive parameters between wild-type, transgenic and mutant zebrafish: Could they all be considered the same "zebrafish" for reglementary assays on endocrine disruption? De Oliveira J, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2021 Jan. PMID 32877737
  4. Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. Xiao Y, et al. Nat Neurosci, 2022 Mar. PMID 35241802, Free PMC Article
  5. Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Song Y, et al. Front Cell Dev Biol, 2021. PMID 35111746, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within immune response IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
properdin
Names
zfp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160126.1 → NP_001153598.1  properdin precursor

    See identical proteins and their annotated locations for NP_001153598.1

    Status: PROVISIONAL

    Source sequence(s)
    BX469917
    UniProtKB/TrEMBL
    A0A8M1NSW8, B0S697
    Related
    ENSDARP00000117151.1, ENSDART00000136865.3
    Conserved Domains (3) summary
    smart00209
    Location:127 → 179
    TSP1; Thrombospondin type 1 repeats
    pfam00090
    Location:72 → 120
    TSP_1; Thrombospondin type 1 domain
    cl15278
    Location:362 → 437
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    23672252..23684659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167038.5 → XP_005167095.1  properdin isoform X1

    See identical proteins and their annotated locations for XP_005167095.1

    UniProtKB/TrEMBL
    A0A8M1NSW8, B0S697
    Conserved Domains (3) summary
    smart00209
    Location:127 → 179
    TSP1; Thrombospondin type 1 repeats
    pfam00090
    Location:72 → 120
    TSP_1; Thrombospondin type 1 domain
    cl15278
    Location:362 → 437
    TSP_1; Thrombospondin type 1 domain

  2. XM_005167041.5 → XP_005167098.1  properdin isoform X1

    See identical proteins and their annotated locations for XP_005167098.1

    UniProtKB/TrEMBL
    A0A8M1NSW8, B0S697
    Conserved Domains (3) summary
    smart00209
    Location:127 → 179
    TSP1; Thrombospondin type 1 repeats
    pfam00090
    Location:72 → 120
    TSP_1; Thrombospondin type 1 domain
    cl15278
    Location:362 → 437
    TSP_1; Thrombospondin type 1 domain

  3. XM_017357340.3 → XP_017212829.1  properdin isoform X1

    UniProtKB/TrEMBL
    A0A8M1NSW8, B0S697
    Conserved Domains (3) summary
    smart00209
    Location:127 → 179
    TSP1; Thrombospondin type 1 repeats
    pfam00090
    Location:72 → 120
    TSP_1; Thrombospondin type 1 domain
    cl15278
    Location:362 → 437
    TSP_1; Thrombospondin type 1 domain
Nucleotide Protein
Heading Accession and Version

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