mhc1zca major histocompatibility complex class I ZCA [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mhc1zcaprovided by ZNC
Official Full Name: major histocompatibility complex class I ZCAprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070424-4
See related: Ensembl:ENSDARG00000069471 AllianceGenome:ZFIN:ZDB-GENE-070424-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dZ63M10.1; zgc:111893; zgc:136614; si:ch211-287j19.5
Summary: Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in gill. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (47140788..47151803, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (46449556..46460570, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: major histocompatibility complex class I ZCA

Names: MHC class I antigen ZCA; dZ63M10.1 (novel MHC class I antigen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083545.1 → NP_001077014.1 major histocompatibility complex class I ZCA precursor

See identical proteins and their annotated locations for NP_001077014.1

Status: PROVISIONAL

Source sequence(s)

BC115196

UniProtKB/TrEMBL

A4FUM4, U6BRB7

Related

ENSDARP00000063528.6, ENSDART00000063529.8

Conserved Domains (2) summary

cd07698
Location:209 → 303

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl08246
Location:22 → 205

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

47140788..47151803 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474930.2 → XP_021330605.1 major histocompatibility complex class I ZCA isoform X1

UniProtKB/TrEMBL

F1QEW6, U6BNA4

Related

ENSDARP00000039383.7, ENSDART00000039459.8

Conserved Domains (1) summary

cl08246
Location:22 → 205

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2