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prickle1b prickle homolog 1b [ Danio rerio (zebrafish) ]

Gene ID: 556148, updated on 4-Jan-2025

Summary

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Official Symbol
prickle1bprovided by ZNC
Official Full Name
prickle homolog 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2152
See related
Ensembl:ENSDARG00000045694 AllianceGenome:ZFIN:ZDB-GENE-030131-2152
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb98c11; wu:fb98c11; si:ch211-155a11.1
Summary
Predicted to enable zinc ion binding activity. Acts upstream of with a positive effect on motor neuron migration. Acts upstream of or within nervous system development and neural crest cell migration. Predicted to be located in membrane. Is expressed in several structures, including mesoderm; myotome; nervous system; neuroepithelial cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See prickle1b in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (13963499..13995800, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (13964650..13996960, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type and RNA binding motif 1 Neighboring gene periphilin 1 Neighboring gene pseudouridylate synthase PUS7L-like Neighboring gene uncharacterized LOC137491529 Neighboring gene pseudouridylate synthase PUS7L-like Neighboring gene uncharacterized LOC137491528

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Mapp OM, et al. Dev Dyn, 2010 Jun. PMID 20503357, Free PMC Article
  2. Prickle1 is required for EMT and migration of zebrafish cranial neural crest. Ahsan K, et al. Dev Biol, 2019 Apr 1. PMID 30721665, Free PMC Article
  3. Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. Sun SD, et al. BMC Neurosci, 2016 Dec 12. PMID 27955617, Free PMC Article
  4. Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Mapp OM, et al. Development, 2011 May. PMID 21521740, Free PMC Article
  5. PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration. Davey CF, et al. PLoS Genet, 2016 Mar. PMID 26990447, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. uncovered roles for pk1a and pk1b in the epithelial-to-mesenchymal transition (EMT) of pre-migratory NCCs that precedes their collective migration to the periphery.
    Title: Prickle1 is required for EMT and migration of zebrafish cranial neural crest.
  2. Farnesylation of a tagged Pk1b is required for its nuclear localization and facial branchiomotor neuron migration.
    Title: Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity.
  3. our data suggest that Pk1b function may be required to integrate the multiple migratory cues received by the neurons into polarization instructions for proper posterior movement.
    Title: Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration.
  4. show that anterior hindbrain (r2/r3) motor neuron migration appears to be independent of vangl2 and pk1b functions, and suggest that multiple mechanisms regulate motor neuron migration along the anterior-posterior axis of the zebrafish hindbrain
    Title: Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain.
  5. Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity.
    Title: Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within facial nucleus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hindbrain tangential cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within motor neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect motor neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prickle-like protein 1b
Names
pk1b
prickle homolog 1 b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030098.2 → NP_001025269.1  prickle-like protein 1b

    Status: PROVISIONAL

    Source sequence(s)
    AI588252, AL929504, EB928759
    UniProtKB/TrEMBL
    A0A8M1N760, F2Z4V3
    Related
    ENSDARP00000067176.4, ENSDART00000067177.6
    Conserved Domains (4) summary
    cd09415
    Location:146 → 204
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:209 → 264
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:269 → 327
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:43 → 139
    PET_Prickle; The PET domain of Prickle

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    13963499..13995800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164634.5 → XP_005164691.1  prickle-like protein 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBR2, Q5SP54
    Related
    ENSDARP00000118988.1, ENSDART00000147955.3
    Conserved Domains (4) summary
    cd09415
    Location:137 → 195
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:200 → 255
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:260 → 318
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:34 → 130
    PET_Prickle; The PET domain of Prickle
Nucleotide Protein Strain
Heading Accession and Version

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