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add1 adducin 1 (alpha) [ Danio rerio (zebrafish) ]

Gene ID: 555511, updated on 9-Dec-2024

Summary

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Official Symbol
add1provided by ZNC
Official Full Name
adducin 1 (alpha)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030909-2
See related
Ensembl:ENSDARG00000103962 AllianceGenome:ZFIN:ZDB-GENE-030909-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb787; bZ1H20.1; zgc:158352
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to be active in several cellular components, including adherens junction; cytoskeleton; and postsynaptic density. Is expressed in nervous system and pronephric duct. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See add1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (1990280..2067982, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (1964456..2042190, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2C-like Neighboring gene WD repeat domain 7 Neighboring gene si:rp71-1h20.3 Neighboring gene zinc finger protein ZFP2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Epigenomic analysis reveals prevalent contribution of transposable elements to cis-regulatory elements, tissue-specific expression, and alternative promoters in zebrafish. Lee HJ, et al. Genome Res, 2022 Jul. PMID 35649578, Free PMC Article
  2. adducin 1 is essential for the survival of erythroid precursors via regulating p53 transcription in zebrafish. Yang S, et al. iScience, 2023 Sep 15. PMID 37636049, Free PMC Article
  3. UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Chen RY, et al. Animals (Basel), 2020 Jun 25. PMID 32630437, Free PMC Article
  4. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Tang V, et al. J Pediatr Gastroenterol Nutr, 2016 Nov. PMID 27526058, Free PMC Article
  5. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC158352

General protein information

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Preferred Names
alpha-adducin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079958.1 → NP_001073427.1  alpha-adducin

    See identical proteins and their annotated locations for NP_001073427.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128848
    UniProtKB/TrEMBL
    A0A8N7UYH2, A1A5X4
    Related
    ENSDARP00000138089.1, ENSDART00000171131.2
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    1990280..2067982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215878.1 → XP_068071979.1  alpha-adducin isoform X7

  2. XM_005160942.5 → XP_005160999.1  alpha-adducin isoform X3

    UniProtKB/TrEMBL
    A0A8M2B847
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

  3. XM_068215879.1 → XP_068071980.1  alpha-adducin isoform X9

  4. XM_068215876.1 → XP_068071977.1  alpha-adducin isoform X2

  5. XM_068215877.1 → XP_068071978.1  alpha-adducin isoform X4

  6. XM_021468841.2 → XP_021324516.1  alpha-adducin isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQG8
    Conserved Domains (2) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    cl27351
    Location:648 → 815
    E3_binding; e3 binding domain

  7. XM_021468845.2 → XP_021324520.1  alpha-adducin isoform X8

    UniProtKB/TrEMBL
    A0A8M9PTW3
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

  8. XM_021468842.2 → XP_021324517.1  alpha-adducin isoform X5

    UniProtKB/TrEMBL
    A0A8M9P3B6
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

  9. XM_009295072.4 → XP_009293347.1  alpha-adducin isoform X12

    UniProtKB/TrEMBL
    A0A8M3ATI8
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

  10. XM_021468846.2 → XP_021324521.1  alpha-adducin isoform X11

    UniProtKB/TrEMBL
    A0A8M9PQH2
    Related
    ENSDARP00000139374.1, ENSDART00000160144.2
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

  11. XM_005160946.5 → XP_005161003.1  alpha-adducin isoform X10

    See identical proteins and their annotated locations for XP_005161003.1

    UniProtKB/TrEMBL
    A0A8M2B7V9
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

  12. XM_021468843.2 → XP_021324518.1  alpha-adducin isoform X6

    UniProtKB/TrEMBL
    A0A8M9P3B6
    Conserved Domains (1) summary
    cl00214
    Location:145 → 390
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
Nucleotide Protein Strain
Heading Accession and Version

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