cnnm2a cyclin and CBS domain divalent metal cation transport mediator 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cnnm2aprovided by ZNC
Official Full Name: cyclin and CBS domain divalent metal cation transport mediator 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-36
See related: Ensembl:ENSDARG00000061195 AllianceGenome:ZFIN:ZDB-GENE-050208-36
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7136247; si:ch211-67n3.4
Summary: Predicted to enable magnesium ion transmembrane transporter activity. Acts upstream of or within brain development and magnesium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; digestive system; midbrain hindbrain boundary neural keel; pleuroperitoneal region; and scale. Used to study schizophrenia. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (28617977..28644725)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (28487203..28516711)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables magnesium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in magnesium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within magnesium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within magnesium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: metal transporter CNNM2a

Names: cyclin M2a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001144785.1 → NP_001138257.1 metal transporter CNNM2a

Status: PROVISIONAL

Source sequence(s)

AL928951

UniProtKB/TrEMBL

A0A8M1NR12, A2ATX7

Related

ENSDARP00000081435.5, ENSDART00000087001.6

Conserved Domains (2) summary

cd04590
Location:398 → 518

CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

pfam01595
Location:200 → 374

DUF21; Domain of unknown function DUF21