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myh10 myosin, heavy chain 10, non-muscle [ Danio rerio (zebrafish) ]

Gene ID: 555454, updated on 9-Dec-2024

Summary

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Official Symbol
myh10provided by ZNC
Official Full Name
myosin, heavy chain 10, non-muscleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-162
See related
Ensembl:ENSDARG00000000103 AllianceGenome:ZFIN:ZDB-GENE-030616-162
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dZ204D19.2; wu:fc46h07; wu:fy19d11; si:dz150i12.3
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within actin filament bundle distribution; midbrain-hindbrain boundary morphogenesis; and regulation of cell shape. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including brain; eye; paraxial mesoderm; swim bladder bud; and tail bud. Orthologous to human MYH10 (myosin heavy chain 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See myh10 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (7553104..7658287)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7395905..7501116)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 3a Neighboring gene proliferation-associated 2G4, a Neighboring gene ubinuclein 2a Neighboring gene intraflagellar transport 56

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Huang Y, et al. Gene Expr Patterns, 2013 Oct. PMID 23665442
  2. Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis. Gutzman JH, et al. Dev Biol, 2015 Jan 1. PMID 25446029
  3. Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium. Lin-Jones J, et al. J Comp Neurol, 2009 Mar 10. PMID 19137585, Free PMC Article
  4. Spatiotemporal expression of smooth muscle markers in developing zebrafish gut. Georgijevic S, et al. Dev Dyn, 2007 Jun. PMID 17474123
  5. Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish. Myhre JL, et al. Dev Biol, 2014 Jun 1. PMID 24613615

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament bundle distribution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-10
Names
myosin, heavy polypeptide 10, non-muscle
nm-mhc-b
nonmuscle myosin heavy chain B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    7553104..7658287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302145.4 → XP_009300420.1  myosin-10 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AT40, A0A8M3BA62
    Conserved Domains (8) summary
    cd14920
    Location:102 → 812
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90 → 812
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:889 → 1969
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:37 → 75
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:1705 → 1714
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:1085 → 1170
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:1641 → 1734
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:1528 → 1637
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_009302149.4 → XP_009300424.1  myosin-10 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BD01, A0A8M3B073, F1R3G4, I3ISA3
    Related
    ENSDARP00000125918.1, ENSDART00000151114.2
    Conserved Domains (8) summary
    cd14920
    Location:102 → 790
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90 → 790
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:867 → 1947
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:37 → 75
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:1683 → 1692
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:1063 → 1148
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:1619 → 1712
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:1506 → 1615
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_009302147.4 → XP_009300422.1  myosin-10 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AT40, A0A8M3B359
    Conserved Domains (8) summary
    cd14920
    Location:102 → 796
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90 → 796
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:873 → 1953
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:37 → 75
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:1689 → 1698
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:1069 → 1154
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:1625 → 1718
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:1512 → 1621
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. XM_677954.10 → XP_683046.6  myosin-10 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BD01, A0A8N7USR7, I3ISA3
    Conserved Domains (8) summary
    cd14920
    Location:102 → 774
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:90 → 774
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:851 → 1931
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:37 → 75
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:1667 → 1676
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:1047 → 1132
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:1603 → 1696
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:1490 → 1597
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein Strain
Heading Accession and Version

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