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fcho2 FCH and mu domain containing endocytic adaptor 2 [ Danio rerio (zebrafish) ]

Gene ID: 553949, updated on 2-Nov-2024

Summary

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Official Symbol
fcho2provided by ZNC
Official Full Name
FCH and mu domain containing endocytic adaptor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-228
See related
Ensembl:ENSDARG00000035389 AllianceGenome:ZFIN:ZDB-GENE-050522-228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb304; sb:cb304; wu:fa01a02; zgc:112167; si:ch211-195c22.1
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity and phosphatidylserine binding activity. Acts upstream of or within chordate embryonic development and convergent extension involved in axis elongation. Predicted to be located in membrane. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and plasma membrane. Is expressed in anterior axial hypoblast; hatching gland; immature eye; polster; and yolk syncytial layer. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See fcho2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (35123662..35200779, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (34523509..34600720, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495519 Neighboring gene transmembrane protein 174 Neighboring gene transportin 1 Neighboring gene transfer RNA lysine (anticodon CUU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. BMP2K phosphorylates AP-2 and regulates clathrin-mediated endocytosis. Ramesh ST, et al. Traffic, 2021 Nov. PMID 34480404
  2. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Umasankar PK, et al. Nat Cell Biol, 2012 Apr 8. PMID 22484487, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112167

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin coat assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within convergent extension involved in axis elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane invagination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
F-BAR domain only protein 2
Names
FCH domain only 2
FCH domain only protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020781.2 → NP_001018617.2  F-BAR domain only protein 2

    Status: VALIDATED

    Source sequence(s)
    CR377210, CR751565
    Related
    ENSDARP00000051270.5, ENSDART00000051271.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    35123662..35200779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068221192.1 → XP_068077293.1  F-BAR domain only protein 2 isoform X5

  2. XM_068221199.1 → XP_068077300.1  F-BAR domain only protein 2 isoform X12

    Related
    ENSDARP00000141294.2, ENSDART00000166272.2

  3. XM_068221191.1 → XP_068077292.1  F-BAR domain only protein 2 isoform X4

  4. XM_068221197.1 → XP_068077298.1  F-BAR domain only protein 2 isoform X10

  5. XM_068221190.1 → XP_068077291.1  F-BAR domain only protein 2 isoform X3

  6. XM_068221198.1 → XP_068077299.1  F-BAR domain only protein 2 isoform X11

  7. XM_068221196.1 → XP_068077297.1  F-BAR domain only protein 2 isoform X9

  8. XM_068221195.1 → XP_068077296.1  F-BAR domain only protein 2 isoform X8

  9. XM_068221194.1 → XP_068077295.1  F-BAR domain only protein 2 isoform X7

  10. XM_068221189.1 → XP_068077290.1  F-BAR domain only protein 2 isoform X2

  11. XM_068221193.1 → XP_068077294.1  F-BAR domain only protein 2 isoform X6

  12. XM_068221188.1 → XP_068077289.1  F-BAR domain only protein 2 isoform X1

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394591.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1241..38468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q502I9.1 GenPept UniProtKB/Swiss-Prot:Q502I9

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