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top1a DNA topoisomerase Ia [ Danio rerio (zebrafish) ]

Gene ID: 553496, updated on 4-Jan-2025

Summary

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Official Symbol
top1aprovided by ZNC
Official Full Name
DNA topoisomerase Iaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060616-217
See related
Ensembl:ENSDARG00000070545 AllianceGenome:ZFIN:ZDB-GENE-060616-217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
top1l; wu:fc66a02; zgc:136349
Summary
Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Predicted to act upstream of or within rhythmic process. Predicted to be located in chromosome and nucleus. Predicted to be active in nucleolus. Orthologous to human TOP1 (DNA topoisomerase I). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See top1a in Genome Data Viewer
Location:
chromosome: 11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (25296366..25311680)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (25058750..25074064)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene cylindromatosis (turban tumor syndrome) 2 Neighboring gene zinc fingers and homeoboxes 3a Neighboring gene family with sequence similarity 83 member D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Tiedke J, et al. Biochem Biophys Res Commun, 2013 Nov 22. PMID 24177009
  2. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
  3. Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Kopp R, et al. Physiol Genomics, 2010 Sep. PMID 20571107
  4. Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. White RJ, et al. Elife, 2022 Feb 17. PMID 35175196, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA topological change IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA topoisomerase I, like
Names
topoisomerase (DNA) I, like
NP_001037789.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044324.2 → NP_001037789.1  DNA topoisomerase I, like

    See identical proteins and their annotated locations for NP_001037789.1

    Status: VALIDATED

    Source sequence(s)
    BC050952, BC117588, CR548630
    UniProtKB/TrEMBL
    A0A8M1N957, Q1ED17
    Related
    ENSDARP00000065948.6, ENSDART00000065949.8
    Conserved Domains (4) summary
    smart00435
    Location:353 → 730
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam01028
    Location:425 → 628
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam02919
    Location:208 → 422
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    pfam14370
    Location:688 → 756
    Topo_C_assoc; C-terminal topoisomerase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    25296366..25311680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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