sumf1 sulfatase modifying factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sumf1provided by ZNC
Official Full Name: sulfatase modifying factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060421-3113
See related: Ensembl:ENSDARG00000044203 AllianceGenome:ZFIN:ZDB-GENE-060421-3113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136465
Summary: Predicted to enable formylglycine-generating oxidase activity. Acts upstream of or within several processes, including microglia development; regulation of cartilage development; and sulfolipid metabolic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (39913853..39920105, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (39916317..39922569, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables formylglycine-generating oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycosaminoglycan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microglia development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sulfolipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: formylglycine-generating enzyme

NP_001035430.2

EC 1.13.-.-

XP_005166098.1

EC 1.13.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040340.2 → NP_001035430.2 formylglycine-generating enzyme precursor

Status: VALIDATED

Source sequence(s)

BX957338

UniProtKB/TrEMBL

Q1RM47

Related

ENSDARP00000064902.6, ENSDART00000064903.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

39913853..39920105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166041.5 → XP_005166098.1 formylglycine-generating enzyme isoform X1

UniProtKB/TrEMBL

A0A8M2BDC4, F1QHA4, Q1RM47

Related

ENSDARP00000065090.4, ENSDART00000065091.6

Conserved Domains (2) summary

COG1262
Location:90 → 368

YfmG; Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain [Posttranslational modification, protein turnover, chaperones]

pfam03781
Location:90 → 365

FGE-sulfatase; Sulfatase-modifying factor enzyme 1