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cgnl1 cingulin-like 1 [ Danio rerio (zebrafish) ]

Gene ID: 553350, updated on 4-Jan-2025

Summary

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Official Symbol
cgnl1provided by ZNC
Official Full Name
cingulin-like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-071009-2
See related
Ensembl:ENSDARG00000015805 AllianceGenome:ZFIN:ZDB-GENE-071009-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to be involved in protein localization to cell-cell junction. Predicted to be part of myosin complex. Predicted to be active in bicellular tight junction. Orthologous to human CGNL1 (cingulin like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See cgnl1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52431749..52498228, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (52156732..52223169, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 93 Neighboring gene myocardial zonula adherens protein Neighboring gene transcription factor 12 Neighboring gene zinc finger protein 280D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Schwayer C, et al. Cell, 2019 Oct 31. PMID 31675500
  2. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cingulin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    52431749..52498228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003198999.6 → XP_003199047.1  cingulin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1RNI0, F1R1I5
    Related
    ENSDARP00000104580.2, ENSDART00000129769.4
    Conserved Domains (9) summary
    COG1340
    Location:617 → 949
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam01496
    Location:1177 → 1258
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam03148
    Location:865 → 1237
    Tektin; Tektin family
    pfam05816
    Location:886 → 1093
    TelA; Toxic anion resistance protein (TelA)
    pfam11235
    Location:102 → 253
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam15035
    Location:826 → 948
    Rootletin; Ciliary rootlet component, centrosome cohesion
    pfam16043
    Location:604 → 729
    DUF4795; Domain of unknown function (DUF4795)
    cl02219
    Location:574 → 656
    Bap31; B-cell receptor-associated protein 31-like
    cl19219
    Location:767 → 849
    DUF342; Protein of unknown function (DUF342)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395268.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    259195..268485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474140.2 → XP_021329815.1  cingulin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q944
    Conserved Domains (1) summary
    cl25732
    Location:1 → 157
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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