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lmo7a LIM domain 7a [ Danio rerio (zebrafish) ]

Gene ID: 553341, updated on 4-Jan-2025

Summary

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Official Symbol
lmo7aprovided by ZNC
Official Full Name
LIM domain 7aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030219-74
See related
Ensembl:ENSDARG00000004930 AllianceGenome:ZFIN:ZDB-GENE-030219-74
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc03h03; id:ibd5155; wu:fc03h03; si:dkey-57a22.10
Summary
Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Predicted to act upstream of or within regulation of cell adhesion and regulation of signaling. Is expressed in several structures, including brain; digestive system; eye; immature eye; and pericardial region. Orthologous to human LMO7 (LIM domain 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See lmo7a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21893757..21970132, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (22082888..22159886, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene aconitate decarboxylase 1 Neighboring gene potassium channel tetramerisation domain containing 12.1 Neighboring gene ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) Neighboring gene shugoshin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells. Gomes G, et al. Int J Mol Sci, 2021 Nov 28. PMID 34884689, Free PMC Article
  2. The lim domain only protein 7 is important in zebrafish heart development. Ott EB, et al. Dev Dyn, 2008 Dec. PMID 19035355
  3. Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. Li YF, et al. PLoS Biol, 2022 Nov. PMID 36318514, Free PMC Article
  4. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
  5. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of signaling IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LIM domain only protein 7
Names
LIM domain only 7a
lmo7
NP_001121703.1
XP_009302886.1
XP_009302897.1
XP_021334325.1
XP_021334326.1
XP_068079478.1
XP_068079479.1
XP_068079480.1
XP_068079481.1
XP_068079482.1
XP_068079483.1
XP_068079484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128231.1 → NP_001121703.1  LIM domain only protein 7

    Status: PROVISIONAL

    Source sequence(s)
    CR536604
    UniProtKB/TrEMBL
    A0A8M1NHP5, A0A8M9QAP1, B0UYM8
    Related
    ENSDARP00000027005.9, ENSDART00000009920.11
    Conserved Domains (7) summary
    COG3144
    Location:954 → 1163
    FliK; Flagellar hook-length control protein FliK [Cell motility]
    cd00136
    Location:1184 → 1245
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:1757 → 1815
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam00307
    Location:20 → 98
    CH; Calponin homology (CH) domain
    pfam15949
    Location:733 → 880
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1382 → 1424
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:1383 → 1468
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    21893757..21970132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223383.1 → XP_068079484.1  LIM domain only protein 7 isoform X11

    UniProtKB/TrEMBL
    A0A8M9QAP5

  2. XM_068223382.1 → XP_068079483.1  LIM domain only protein 7 isoform X10

    UniProtKB/TrEMBL
    A0A8M9Q4K1

  3. XM_068223379.1 → XP_068079480.1  LIM domain only protein 7 isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q4J8

  4. XM_009304622.4 → XP_009302897.1  LIM domain only protein 7 isoform X7

    UniProtKB/TrEMBL
    A0A8M3B2L7, A0A8M9PS15
    Conserved Domains (7) summary
    COG3144
    Location:954 → 1163
    FliK; Flagellar hook-length control protein FliK [Cell motility]
    cd00136
    Location:1184 → 1245
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:1793 → 1851
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam00307
    Location:20 → 98
    CH; Calponin homology (CH) domain
    pfam15949
    Location:733 → 880
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1365 → 1407
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:1366 → 1451
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  5. XM_021478651.2 → XP_021334326.1  LIM domain only protein 7 isoform X6

    UniProtKB/TrEMBL
    A0A8M9PS15, A0A8M9QFC6
    Conserved Domains (6) summary
    cd00014
    Location:17 → 128
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00136
    Location:1184 → 1245
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:1807 → 1865
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:733 → 881
    DUF4757; Domain of unknown function (DUF4757)
    cl25574
    Location:809 → 1096
    TOP2c; TopoisomeraseII
    cl26511
    Location:1379 → 1489
    Neuromodulin_N; Gap junction protein N-terminal region

  6. XM_009304611.4 → XP_009302886.1  LIM domain only protein 7 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AVY5, A0A8M9PS15
    Conserved Domains (7) summary
    COG3144
    Location:954 → 1163
    FliK; Flagellar hook-length control protein FliK [Cell motility]
    cd00136
    Location:1184 → 1245
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:1810 → 1868
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam00307
    Location:20 → 98
    CH; Calponin homology (CH) domain
    pfam15949
    Location:733 → 880
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1382 → 1424
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:1383 → 1468
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  7. XM_021478650.2 → XP_021334325.1  LIM domain only protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PS15, A0A8M9QJL3
    Conserved Domains (6) summary
    cd00014
    Location:17 → 128
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00136
    Location:1184 → 1245
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:1824 → 1882
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:733 → 881
    DUF4757; Domain of unknown function (DUF4757)
    cl25574
    Location:809 → 1096
    TOP2c; TopoisomeraseII
    cl26511
    Location:1396 → 1506
    Neuromodulin_N; Gap junction protein N-terminal region

  8. XM_068223381.1 → XP_068079482.1  LIM domain only protein 7 isoform X9

    UniProtKB/TrEMBL
    A0A8M9QJL5

  9. XM_068223378.1 → XP_068079479.1  LIM domain only protein 7 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PS15

  10. XM_068223380.1 → XP_068079481.1  LIM domain only protein 7 isoform X8

    UniProtKB/TrEMBL
    A0A8M9QAP1

  11. XM_068223377.1 → XP_068079478.1  LIM domain only protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PS15

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395278.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    262756..339066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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