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esyt3 extended synaptotagmin-like protein 3 [ Danio rerio (zebrafish) ]

Gene ID: 553238, updated on 4-Jan-2025

Summary

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Official Symbol
esyt3provided by ZNC
Official Full Name
extended synaptotagmin-like protein 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-050809-35
See related
Ensembl:ENSDARG00000006422 AllianceGenome:ZFIN:ZDB-GENE-050809-35
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
FAM62A; im:7153182; si:ch211-219a4.7
Summary
Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to act upstream of or within endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT3 (extended synaptotagmin 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See esyt3 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (23783856..23807032, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (23972987..23996163, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene Fas apoptotic inhibitory molecule a Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene poly(ADP-ribose) polymerase family member 14-related sequence 1 Neighboring gene transfer RNA leucine (anticodon CAA) Neighboring gene dehydrogenase/reductase (SDR family) member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. Li F, et al. PLoS One, 2016. PMID 27046191, Free PMC Article
  2. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article
  3. A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. Craxton M. BMC Genomics, 2010 Jan 15. PMID 20078875, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endoplasmic reticulum-plasma membrane tethering IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
extended synaptotagmin-3
Names
fam62c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123233.1 → NP_001116705.1  extended synaptotagmin-3

    Status: PROVISIONAL

    Source sequence(s)
    CR533429
    UniProtKB/TrEMBL
    A0A8M1NG28, B0UYL4
    Related
    ENSDARP00000010917.7, ENSDART00000027443.8
    Conserved Domains (4) summary
    cd04030
    Location:726 → 850
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:443 → 567
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:302 → 422
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:109 → 287
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    23783856..23807032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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