U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

klf7b Kruppel like factor 7b [ Danio rerio (zebrafish) ]

Gene ID: 553082, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
klf7bprovided by ZNC
Official Full Name
Kruppel like factor 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041014-171
See related
Ensembl:ENSDARG00000043821 AllianceGenome:ZFIN:ZDB-GENE-041014-171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
klf7l; zgc:153366; si:dkey-101c24.1
Summary
Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within optic nerve formation. Is expressed in nervous system; neural rod; and trigeminal placode. Orthologous to human KLF7 (KLF transcription factor 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See klf7b in Genome Data Viewer
Location:
chromosome: 9
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (28344497..28399071, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (28533751..28588325, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cyclin Y-like 1 Neighboring gene cAMP responsive element binding protein 1b Neighboring gene si:ch73-7i4.1 Neighboring gene uncharacterized LOC101884404

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous system. Bhattarai S, et al. Gene Expr Patterns, 2016 May. PMID 27364471, Free PMC Article
  2. Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Veldman MB, et al. Mol Cell Neurosci, 2010 Apr. PMID 20123021, Free PMC Article
  3. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Veldman MB, et al. Dev Biol, 2007 Dec 15. PMID 17949705
  4. Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Shao M, et al. Oncotarget, 2017 Mar 7. PMID 28032601, Free PMC Article
  5. Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. Elsaeidi F, et al. J Neurosci, 2014 Feb 12. PMID 24523552, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within optic nerve formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Krueppel-like factor 7b
Names
Kruppel-like factor 7 (ubiquitous), like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044766.2 → NP_001038231.1  Krueppel-like factor 7b

    See identical proteins and their annotated locations for NP_001038231.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124329
    UniProtKB/TrEMBL
    B2GS50, Q5TYN4
    Related
    ENSDARP00000095092.2, ENSDART00000104317.5
    Conserved Domains (3) summary
    COG5048
    Location:205 → 277
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258 → 283
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    28344497..28399071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools