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ALAS1 5'-aminolevulinate synthase 1 [ Gallus gallus (chicken) ]

Gene ID: 552895, updated on 3-Dec-2024

Summary

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Symbol
ALAS1provided by CGNC
Full Name
5'-aminolevulinate synthase 1provided by CGNC
Primary source
CGNC:2897
See related
Ensembl:ENSGALG00010027410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ALAS2; ALASE; ALASN; ALAS-E
Orthologs
human mouse all
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Genomic context

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See ALAS1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (3121084..3127944)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (3170637..3177489)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 2-like Neighboring gene maestro heat-like repeat-containing protein family member 7 Neighboring gene HEAT repeat-containing protein 8 like 3 Neighboring gene IQ motif containing F6 Neighboring gene glutamate metabotropic receptor 2 Neighboring gene twinfilin actin binding protein 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor. Borthwick IA, et al. Eur J Biochem, 1985 Aug 1. PMID 3839458
  2. Nucleotide sequence of the chicken 5-aminolevulinate synthase gene. Maguire DJ, et al. Nucleic Acids Res, 1986 Feb 11. PMID 3005973, Free PMC Article
  3. Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes. Riddle RD, et al. Proc Natl Acad Sci U S A, 1989 Feb. PMID 2915978, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5-aminolevulinate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial
Names
5'-aminolevulinate synthase 2
5-aminolevulinate synthase, erythroid-specific, mitochondrial
5-aminolevulinic acid synthase 1
5-aminolevulinic acid synthase 2
ALA-synthase
ALAS-H
Delta-ALA synthase 2
Delta-aminolevulinate synthase 2
aminolevulinate, delta-, synthase 1
delta-ALA synthase 1
delta-aminolevulinate synthase 1
NP_001018012.2
XP_025010275.1
XP_046782444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018012.2 → NP_001018012.2  5-aminolevulinate synthase, non-specific, mitochondrial precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000252
    UniProtKB/Swiss-Prot
    P07997
    UniProtKB/TrEMBL
    A0A1D5P0L4
    Related
    ENSGALP00010040723.1, ENSGALT00010066465.1
    Conserved Domains (1) summary
    cl18945
    Location:192 → 597
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3121084..3127944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025154507.2 → XP_025010275.1  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P07997
    UniProtKB/TrEMBL
    A0A8V1ABX4
    Related
    ENSGALP00010040722.1, ENSGALT00010066462.1
    Conserved Domains (2) summary
    pfam09029
    Location:2 → 131
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:140 → 545
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3170637..3177489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926488.1 → XP_046782444.1  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P07997
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07997.2 GenPept UniProtKB/Swiss-Prot:P07997

Gene LinkOut

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