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mllt3 MLLT3 super elongation complex subunit [ Danio rerio (zebrafish) ]

Gene ID: 550517, updated on 9-Dec-2024

Summary

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Official Symbol
mllt3provided by ZNC
Official Full Name
MLLT3 super elongation complex subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-356
See related
Ensembl:ENSDARG00000006754 AllianceGenome:ZFIN:ZDB-GENE-050417-356
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc39c11; wu:fc39c11; zgc:110210
Summary
Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including digestive system; intermediate cell mass of mesoderm; nervous system; paraxial mesoderm; and pronephros. Orthologous to human MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See mllt3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (18779555..18881358, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (18527288..18629091, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkey-38l22.2 Neighboring gene tRNA methyltransferase 10A Neighboring gene focadhesin Neighboring gene zgc:194252 Neighboring gene C-type mannose receptor 2-like Neighboring gene 3-hydroxyacyl-CoA dehydratase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The transcriptional landscape of hematopoietic stem cell ontogeny. McKinney-Freeman S, et al. Cell Stem Cell, 2012 Nov 2. PMID 23122293, Free PMC Article
  2. Leukemia-associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis. Germano G, et al. Dev Dyn, 2022 Oct. PMID 35429189
  3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leukemia-associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis.
    Title: Leukemia-associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein AF-9
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017819.1 → NP_001017819.1  protein AF-9

    See identical proteins and their annotated locations for NP_001017819.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092798
    UniProtKB/TrEMBL
    Q568M5
    Related
    ENSDARP00000004230.6, ENSDART00000021502.9
    Conserved Domains (1) summary
    pfam03366
    Location:1 → 77
    YEATS; YEATS family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    18779555..18881358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477527.2 → XP_021333202.1  protein AF-9 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PNX3
    Conserved Domains (1) summary
    pfam03366
    Location:1 → 77
    YEATS; YEATS family

  2. XM_009303057.4 → XP_009301332.1  protein AF-9 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BAV5
    Conserved Domains (1) summary
    pfam03366
    Location:29 → 109
    YEATS; YEATS family
Nucleotide Protein Strain
Heading Accession and Version

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