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prmt3 protein arginine methyltransferase 3 [ Danio rerio (zebrafish) ]

Gene ID: 550348, updated on 9-Dec-2024

Summary

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Official Symbol
prmt3provided by ZNC
Official Full Name
protein arginine methyltransferase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-041105-1
See related
Ensembl:ENSDARG00000019791 AllianceGenome:ZFIN:ZDB-GENE-041105-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hrmt1l3; zgc:112498
Summary
Predicted to enable histone methyltransferase activity and protein-arginine N-methyltransferase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to act upstream of or within peptidyl-arginine methylation. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human PRMT3 (protein arginine methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See prmt3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (17106270..17223535)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (16854300..16971562)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496160 Neighboring gene HIV-1 Tat interactive protein 2 Neighboring gene solute carrier family 6 member 5 Neighboring gene novel immune-type receptor 12 Neighboring gene novel immune-type receptor 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish prmt3 negatively regulates antiviral responses. Zhu J, et al. FASEB J, 2020 Aug. PMID 32643209
  2. Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Hung CM, et al. Gene, 2004 Oct 13. PMID 15475159
  3. Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Dong CW, et al. Fish Shellfish Immunol, 2007 Apr. PMID 17055744
  4. The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains. Desai S, et al. BMC Evol Biol, 2008 Jun 19. PMID 18565225, Free PMC Article
  5. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-arginine methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein arginine N-methyltransferase 3
Names
HMT1 hnRNP methyltransferase-like 3
NP_001017655.1
XP_009301243.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017655.1 → NP_001017655.1  protein arginine N-methyltransferase 3

    See identical proteins and their annotated locations for NP_001017655.1

    Status: PROVISIONAL

    Source sequence(s)
    BC093344
    UniProtKB/TrEMBL
    Q566T5
    Related
    ENSDARP00000003829.6, ENSDART00000013409.8
    Conserved Domains (2) summary
    pfam12756
    Location:39 → 86
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam12847
    Location:236 → 340
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    17106270..17223535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302968.4 → XP_009301243.1  protein arginine N-methyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8QI13, A0A8M3ATX2
    Related
    ENSDARP00000153690.1, ENSDART00000190048.1
    Conserved Domains (2) summary
    cd02440
    Location:231 → 331
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam12756
    Location:30 → 77
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
Nucleotide Protein
Heading Accession and Version

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