alad aminolevulinate dehydratase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aladprovided by ZNC
Official Full Name: aminolevulinate dehydrataseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-123
See related: Ensembl:ENSDARG00000100372 AllianceGenome:ZFIN:ZDB-GENE-050417-123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110219; CH73-203I15.1
Summary: Predicted to enable porphobilinogen synthase activity and zinc ion binding activity. Predicted to be involved in heme biosynthetic process. Predicted to act upstream of or within porphyrin-containing compound biosynthetic process. Predicted to be active in cytosol. Is expressed in blood and ventral mesoderm. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (54482976..54497040, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (53836383..53850447, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables porphobilinogen synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables porphobilinogen synthase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tetrapyrrole biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: delta-aminolevulinic acid dehydratase

NP_001017645.1

EC 4.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017645.1 → NP_001017645.1 delta-aminolevulinic acid dehydratase

See identical proteins and their annotated locations for NP_001017645.1

Status: PROVISIONAL

Source sequence(s)

BC092804

UniProtKB/TrEMBL

Q568L9

Related

ENSDARP00000136768.1, ENSDART00000160492.2

Conserved Domains (1) summary

cd04824
Location:10 → 329

eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...