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FBXO34 F-box protein 34 [ Homo sapiens (human) ]

Gene ID: 55030, updated on 27-Nov-2024

Summary

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Official Symbol
FBXO34provided by HGNC
Official Full Name
F-box protein 34provided by HGNC
Primary source
HGNC:HGNC:20201
See related
Ensembl:ENSG00000178974 MIM:609104; AllianceGenome:HGNC:20201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbx34; CGI-301
Summary
Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 12.2), esophagus (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

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See FBXO34 in Genome Data Viewer
Location:
14q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55271421..55443049)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49476645..49562228)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55738139..55820329)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 L1 (pseudogene) Neighboring gene cytochrome c oxidase subunit 5A pseudogene 1 Neighboring gene FBXO34 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8428 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:55754571-55754700 Neighboring gene ribosomal protein L34 pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 9702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8430 Neighboring gene charged multivesicular body protein 4B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8431 Neighboring gene NANOG hESC enhancer GRCh37_chr14:55794909-55795410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8432 Neighboring gene autophagy related 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5783 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 6 Neighboring gene TATA-box binding protein like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8433 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:55914403-55915602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5784 Neighboring gene ribosomal protein L7a pseudogene 4 Neighboring gene abl interactor 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation. Yang X, et al. Emerg Microbes Infect, 2022 Dec. PMID 36285453, Free PMC Article
  2. F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. Tian X, et al. Oncotarget, 2015 Sep 8. PMID 26087183, Free PMC Article
  3. Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening. Falconieri A, et al. Cancers (Basel), 2022 Feb 17. PMID 35205757, Free PMC Article
  4. Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Reitsma JM, et al. Cell, 2017 Nov 30. PMID 29103612, Free PMC Article
  5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation.
    Title: FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20725, MGC126434, MGC126435, DKFZp547C162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 34
Names
protein CGI-301

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017943.4 → NP_060413.2  F-box only protein 34

    See identical proteins and their annotated locations for NP_060413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more frequently occurring and longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AI911690, BC109120
    Consensus CDS
    CCDS32086.1
    UniProtKB/Swiss-Prot
    Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
    UniProtKB/TrEMBL
    G3V2U9
    Related
    ENSP00000313159.4, ENST00000313833.5
    Conserved Domains (1) summary
    pfam12937
    Location:575 → 609
    F-box-like; F-box-like

  2. NM_152231.2 → NP_689417.1  F-box only protein 34

    See identical proteins and their annotated locations for NP_689417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL158801
    Consensus CDS
    CCDS32086.1
    UniProtKB/Swiss-Prot
    Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
    UniProtKB/TrEMBL
    G3V2U9
    Related
    ENSP00000394117.1, ENST00000440021.1
    Conserved Domains (1) summary
    pfam12937
    Location:575 → 609
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    55271421..55443049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720185.4 → XP_006720248.1  F-box only protein 34 isoform X2

    See identical proteins and their annotated locations for XP_006720248.1

    UniProtKB/Swiss-Prot
    Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
    UniProtKB/TrEMBL
    G3V2U9
    Related
    ENSP00000450877.1, ENST00000555280.1
    Conserved Domains (1) summary
    pfam12937
    Location:575 → 609
    F-box-like; F-box-like

  2. XM_017021391.2 → XP_016876880.1  F-box only protein 34 isoform X1

    UniProtKB/TrEMBL
    G3V2U9

  3. XM_017021393.3 → XP_016876882.1  F-box only protein 34 isoform X2

    UniProtKB/Swiss-Prot
    Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
    UniProtKB/TrEMBL
    G3V2U9
    Conserved Domains (1) summary
    pfam12937
    Location:575 → 609
    F-box-like; F-box-like

RNA

  1. XR_007064026.1 RNA Sequence

  2. XR_007064028.1 RNA Sequence

  3. XR_007064027.1 RNA Sequence

  4. XR_007064025.1 RNA Sequence

  5. XR_007064023.1 RNA Sequence

  6. XR_007064022.1 RNA Sequence

  7. XR_007064024.1 RNA Sequence

  8. XR_007064021.1 RNA Sequence

  9. XR_007064020.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    49476645..49562228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376283.1 → XP_054232258.1  F-box only protein 34 isoform X2

    UniProtKB/Swiss-Prot
    Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3

  2. XM_054376281.1 → XP_054232256.1  F-box only protein 34 isoform X1

  3. XM_054376282.1 → XP_054232257.1  F-box only protein 34 isoform X2

    UniProtKB/Swiss-Prot
    Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3

RNA

  1. XR_008488881.1 RNA Sequence

  2. XR_008488880.1 RNA Sequence

  3. XR_008488879.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWN3.2 GenPept UniProtKB/Swiss-Prot:Q9NWN3

Gene LinkOut

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