ca8 carbonic anhydrase VIII [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ca8provided by ZNC
Official Full Name: carbonic anhydrase VIIIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-26
See related: Ensembl:ENSDARG00000039098 AllianceGenome:ZFIN:ZDB-GENE-050417-26
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110118
Summary: Predicted to enable carbonate dehydratase activity and zinc ion binding activity. Acts upstream of or within cerebellum development; chordate embryonic development; and swimming behavior. Is expressed in several structures, including brain; digestive system; hatching gland; hindbrain neural plate; and pleuroperitoneal region. Used to study cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 3. Orthologous to human CA8 (carbonic anhydrase 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (21854916..21878527)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (22196972..22220465)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CA8 overexpression desensitizes neuronal cells to STS induced apoptotic stress and increases cell migration and invasion ability in neuronal cells.
Title: Roles of carbonic anhydrase 8 in neuronal cells and zebrafish.
We provide evidence that the CA8 gene product is indispensable in early embryonic development in zebra fi sh, particularly in the brain and eye.
Title: Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish.

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General gene information

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Markers

G39618 (e-PCR)
- UniSTS:31582

fc70b09.y1 (e-PCR)
- UniSTS:194299

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: carbonic anhydrase-related protein

Names: CARP VIII

NP_001017571.2

EC 4.2.1.1

XP_068080124.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017571.2 → NP_001017571.2 carbonic anhydrase-related protein

Status: VALIDATED

Source sequence(s)

CR847864

UniProtKB/TrEMBL

Q568S6

Related

ENSDARP00000116974.1, ENSDART00000140012.2

Conserved Domains (1) summary

cd03120
Location:25 → 280

alpha_CARP_VIII; Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a ...