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septin10 septin 10 [ Danio rerio (zebrafish) ]

Gene ID: 550129, updated on 9-Dec-2024

Summary

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Official Symbol
septin10provided by ZNC
Official Full Name
septin 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-3
See related
Ensembl:ENSDARG00000099236 AllianceGenome:ZFIN:ZDB-GENE-050417-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sept10; wu:fb22c05; wu:fc15g06; zgc:110575
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including SEPTIN10 (septin 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See septin10 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (55857193..55875077)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (56507489..56525415)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene A kinase (PRKA) anchor protein 17A Neighboring gene acetylserotonin O-methyltransferase Neighboring gene sosondowah ankyrin repeat domain family Ca Neighboring gene SH3 domain containing ring finger 1-like Neighboring gene uncharacterized LOC137496516 Neighboring gene ectodysplasin A receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425
  2. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
septin 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017557.1 → NP_001017557.1  septin 10

    See identical proteins and their annotated locations for NP_001017557.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092936
    UniProtKB/TrEMBL
    A0A8M1N4W8, Q568B3
    Related
    ENSDARP00000139839.1, ENSDART00000160980.2
    Conserved Domains (3) summary
    cd01850
    Location:39 → 307
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:20 → 404
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl21478
    Location:324 → 410
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    55857193..55875077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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