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nek12 NIMA-related kinase 12 [ Danio rerio (zebrafish) ]

Gene ID: 548344, updated on 9-Dec-2024

Summary

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Official Symbol
nek12provided by ZNC
Official Full Name
NIMA-related kinase 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-050410-11
See related
Ensembl:ENSDARG00000037174 AllianceGenome:ZFIN:ZDB-GENE-050410-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:113355
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in DNA damage response. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See nek12 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (28425029..28432699, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (28118921..28126741, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene formin-2-like Neighboring gene TSC22 domain family, member 3 Neighboring gene midline 2 Neighboring gene acyl-CoA synthetase long chain family member 4a Neighboring gene protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) Neighboring gene nuclear transport factor 2-like export factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NIMA-related kinase 12
NP_001017548.1
XP_005173227.1
XP_005173228.1
XP_068069305.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017548.2 → NP_001017548.1  NIMA-related kinase 12

    See identical proteins and their annotated locations for NP_001017548.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092172
    UniProtKB/TrEMBL
    B2GRM7, Q56A46
    Related
    ENSDARP00000054061.4, ENSDART00000054062.5
    Conserved Domains (2) summary
    smart00220
    Location:4 → 262
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08215
    Location:3 → 262
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    28425029..28432699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213204.1 → XP_068069305.1  NIMA-related kinase 12 isoform X1

    UniProtKB/TrEMBL
    B2GRM7, Q56A46

  2. XM_005173171.5 → XP_005173228.1  NIMA-related kinase 12 isoform X1

    See identical proteins and their annotated locations for XP_005173228.1

    UniProtKB/TrEMBL
    B2GRM7, Q56A46
    Conserved Domains (2) summary
    smart00220
    Location:4 → 262
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08215
    Location:3 → 262
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

  3. XM_005173170.5 → XP_005173227.1  NIMA-related kinase 12 isoform X1

    See identical proteins and their annotated locations for XP_005173227.1

    UniProtKB/TrEMBL
    B2GRM7, Q56A46
    Conserved Domains (2) summary
    smart00220
    Location:4 → 262
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08215
    Location:3 → 262
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase
Nucleotide Protein Strain
Heading Accession and Version

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