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Spag11b sperm associated antigen 11B [ Mus musculus (house mouse) ]

Gene ID: 546038, updated on 9-Dec-2024

Summary

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Official Symbol
Spag11bprovided by MGI
Official Full Name
sperm associated antigen 11Bprovided by MGI
Primary source
MGI:MGI:3647173
See related
Ensembl:ENSMUSG00000059463 AllianceGenome:MGI:3647173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ep2e; Bin1b; Ep2c/h; Spag11; EG546038; Spag11c/h
Summary
Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and cytolysis by host of symbiont cells. Predicted to be located in extracellular region. Orthologous to human SPAG11B (sperm associated antigen 11B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward genital fat pad adult (RPKM 854.9) See more
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Genomic context

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See Spag11b in Genome Data Viewer
Location:
8 A1.3; 8 10.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (19190775..19193026)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (19140759..19143010)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin beta 12 Neighboring gene defensin beta 34 Neighboring gene sperm associated antigen 11A Neighboring gene predicted gene, 53432

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Patil AA, et al. Physiol Genomics, 2005 Sep 21. PMID 16033865
  2. Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. Amid C, et al. BMC Genomics, 2009 Dec 15. PMID 20003482, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in cytolysis by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm-associated antigen 11B
Names
Sperm-associated antigen 11
beta-defensin-like peptide
sperm-associated antigen 11c/h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034905.2 → NP_001030077.1  sperm-associated antigen 11B isoform 3 precursor

    See identical proteins and their annotated locations for NP_001030077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also called h) includes a 3' terminal exon which extends past a splice site that is used in variant 1. It encodes isoform 3 (also called h) which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK136627
    Consensus CDS
    CCDS40251.1
    UniProtKB/TrEMBL
    Q3UW43
    Related
    ENSMUSP00000106395.2, ENSMUST00000110767.2
    Conserved Domains (1) summary
    pfam05324
    Location:8 → 71
    Sperm_Ag_HE2; Sperm antigen HE2

  2. NM_001039563.3 → NP_001034652.2  sperm-associated antigen 11B isoform c precursor

    See identical proteins and their annotated locations for NP_001034652.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform 1.
    Source sequence(s)
    AK136627, DQ012055
    Consensus CDS
    CCDS22133.1
    UniProtKB/Swiss-Prot
    Q2HPE2, Q3UW43
    UniProtKB/TrEMBL
    Q2HPE3
    Related
    ENSMUSP00000048125.8, ENSMUST00000039075.8
    Conserved Domains (1) summary
    pfam05324
    Location:8 → 72
    Sperm_Ag_HE2; Sperm antigen HE2

  3. NM_001286493.1 → NP_001273422.1  sperm-associated antigen 11B isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC116394, AK136627, DQ012055
    UniProtKB/TrEMBL
    B7ZNZ8
    Conserved Domains (1) summary
    pfam05324
    Location:8 → 73
    Sperm_Ag_HE2; Sperm antigen HE2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    19190775..19193026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UW43.2 GenPept UniProtKB/Swiss-Prot:Q3UW43

Gene LinkOut

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