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Smok3a sperm motility kinase 3A [ Mus musculus (house mouse) ]

Gene ID: 545814, updated on 27-Nov-2024

Summary

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Official Symbol
Smok3aprovided by MGI
Official Full Name
sperm motility kinase 3Aprovided by MGI
Primary source
MGI:MGI:3693943
See related
Ensembl:ENSMUSG00000075599 AllianceGenome:MGI:3693943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smok2b1
Summary
Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 10.2) See more
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Genomic context

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See Smok3a in Genome Data Viewer
Location:
5 G2; 5 76.93 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138019538..138032927)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138021276..138034665)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene alpha-2-glycoprotein 1, zinc Neighboring gene predicted gene 4963 Neighboring gene STARR-seq mESC enhancer starr_14662 Neighboring gene STARR-seq mESC enhancer starr_14663 Neighboring gene sperm motility kinase 3B Neighboring gene sperm motility kinase 3C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Herrmann BG, et al. Nature, 1999 Nov 11. PMID 10647005
  2. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sperm motility kinase 3A
Names
sperm motility kinase 2B1
sperm motility kinase 3
NP_001119517.1
NP_001162073.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126045.1 → NP_001119517.1  sperm motility kinase 3A

    See identical proteins and their annotated locations for NP_001119517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a split 3' exon, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125212
    Consensus CDS
    CCDS51678.1
    UniProtKB/Swiss-Prot
    C0HKC8, C0HKC9, Q9QYZ5
    UniProtKB/TrEMBL
    B9EKK5
    Related
    ENSMUSP00000125938.2, ENSMUST00000171498.3
    Conserved Domains (2) summary
    cd14337
    Location:295 → 334
    UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
    cd14003
    Location:27 → 275
    STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

  2. NM_001168602.1 → NP_001162073.1  sperm motility kinase 3A

    See identical proteins and their annotated locations for NP_001162073.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125212
    Consensus CDS
    CCDS51678.1
    UniProtKB/Swiss-Prot
    C0HKC8, C0HKC9, Q9QYZ5
    UniProtKB/TrEMBL
    B9EKK5
    Related
    ENSMUSP00000083049.3, ENSMUST00000085886.3
    Conserved Domains (2) summary
    cd14337
    Location:295 → 334
    UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
    cd14003
    Location:27 → 275
    STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138019538..138032927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0HKC8.1 GenPept UniProtKB/Swiss-Prot:C0HKC8

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