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CRCT1 cysteine rich C-terminal 1 [ Homo sapiens (human) ]

Gene ID: 54544, updated on 10-Dec-2024

Summary

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Official Symbol
CRCT1provided by HGNC
Official Full Name
cysteine rich C-terminal 1provided by HGNC
Primary source
HGNC:HGNC:29875
See related
Ensembl:ENSG00000169509 MIM:617426; AllianceGenome:HGNC:29875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NICE1; NICE-1; C1orf42
Expression
Biased expression in skin (RPKM 17.3) and esophagus (RPKM 17.1) See more
Orthologs
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Genomic context

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See CRCT1 in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152514482..152516008)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151651031..151652559)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152486958..152488484)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cornulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1732 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:152443806-152444710 Neighboring gene late cornified envelope 5A Neighboring gene late cornified envelope 3E Neighboring gene late cornified envelope 3D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer. Wu N, et al. Tumour Biol, 2016 Jun. PMID 26718216
  2. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. Marenholz I, et al. Genome Res, 2001 Mar. PMID 11230159, Free PMC Article
  3. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Torgerson DG, et al. Nat Genet, 2011 Jul 31. PMID 21804549, Free PMC Article
  4. Network-based prediction of protein interactions. Kovács IA, et al. Nat Commun, 2019 Mar 18. PMID 30886144, Free PMC Article
  5. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRCT1 functions as a tumor suppressor gene in ESCC and is regulated by miR-520 g, providing potential therapeutic targets for the treatment of ESCC
    Title: CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
cysteine-rich C-terminal protein 1
Names
protein NICE-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019060.3 → NP_061933.1  cysteine-rich C-terminal protein 1

    See identical proteins and their annotated locations for NP_061933.1

    Status: VALIDATED

    Source sequence(s)
    AJ243662, AL135842
    Consensus CDS
    CCDS1012.1
    UniProtKB/Swiss-Prot
    A4QN00, Q6IAD7, Q9UGL9
    Related
    ENSP00000357779.3, ENST00000368790.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152514482..152516008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509656.3 → XP_011507958.1  cysteine-rich C-terminal protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011507958.1

    UniProtKB/Swiss-Prot
    A4QN00, Q6IAD7, Q9UGL9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    151651031..151652559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337138.1 → XP_054193113.1  cysteine-rich C-terminal protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4QN00, Q6IAD7, Q9UGL9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGL9.1 GenPept UniProtKB/Swiss-Prot:Q9UGL9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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