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Sstr2 somatostatin receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54305, updated on 27-Nov-2024

Summary

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Official Symbol
Sstr2provided by RGD
Official Full Name
somatostatin receptor 2provided by RGD
Primary source
RGD:3763
See related
EnsemblRapid:ENSRNOG00000002793 AllianceGenome:RGD:3763
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Smstr2
Summary
Enables PDZ domain binding activity and somatostatin receptor activity. Involved in several processes, including brain development; cellular response to estradiol stimulus; and peristalsis. Predicted to be located in cytosol and membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Predicted to be active in neuron projection and plasma membrane. Orthologous to human SSTR2 (somatostatin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 48.4), Brain (RPKM 31.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sstr2 in Genome Data Viewer
Location:
10q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (99163353..99170519)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98664204..98671370)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (102136283..102143449)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39, member 11 Neighboring gene uncharacterized LOC120095210 Neighboring gene transfer RNA alanine (anticodon UGC) 10 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The somatostatin sst2A receptor in the rat trigeminal ganglion. Ichikawa H, et al. Neuroscience, 2003. PMID 12895520
  2. Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticus. Kozhemyakin M, et al. Neurobiol Dis, 2013 Jun. PMID 23473742, Free PMC Article
  3. Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2. Hortala M, et al. J Biol Chem, 2003 Jun 6. PMID 12665520
  4. Suppression of ANP secretion by somatostatin through somatostatin receptor type 2. Gao S, et al. Peptides, 2011 Jun. PMID 21539874
  5. Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats. Stengel A, et al. J Physiol Pharmacol, 2010 Aug. PMID 20814067, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat Model of Chronic Anxiety.
    Title: Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat Model of Chronic Anxiety.
  2. Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly.
    Title: Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly.
  3. Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells.
    Title: Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells.
  4. study suggests that SSTR2 might play a critical role in the aetiopathogenesis of periodontitis
    Title: Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues.
  5. suckling-induced activation of SST-SSTR2 signaling mediates, at least in part, the suppression of pulsatile LH secretion during lactation
    Title: Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats.
  6. Somatostatin 2 Receptor Activation in the Rostral Ventrolateral Medulla Does Not Mediate the Decompensatory Phase of Haemorrhage.
    Title: Somatostatin 2 Receptor Activation in the Rostral Ventrolateral Medulla Does Not Mediate the Decompensatory Phase of Haemorrhage.
  7. In a chronic mild stress model, sst2 and sst4 expression increases in the habenula following imipramine treatment.
    Title: Behavioral response to imipramine under chronic mild stress corresponds with increase of mRNA encoding somatostatin receptors sst2 and sst4 expression in medial habenular nucleus.
  8. This study demonstrated that SSTR2 associated with neuronal apoptosis after intracerebral hemorrhage in adult rats.
    Title: SSTR2 associated with neuronal apoptosis after intracerebral hemorrhage in adult rats.
  9. In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy decreased mRNA levels of SSTR2 on day 14 post-infection, although it increased mRNA levels of SSTR2 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model.
    Title: Octreotide modulates the expression of somatostatin receptor subtypes in inflamed rat jejunum induced by Cryptosporidium parvum.
  10. Chronic mild stress causes significant up-regulation of sst2 receptor in medial habenula
    Title: Chronic mild stress alters the somatostatin receptors in the rat brain.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables somatostatin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables somatostatin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in forebrain development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peristalsis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of G protein-coupled receptor heterodimeric complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
somatostatin receptor type 2
Names
SRIF-1
SS-2-R
SS2-R
SS2R
somatostatin receptor subtype 2
somatotropin release-inhibiting factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019348.2 → NP_062221.1  somatostatin receptor type 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P30680
    UniProtKB/TrEMBL
    A6HKF9, A6HKG0
    Related
    ENSRNOP00000110504.1, ENSRNOT00000133830.1
    Conserved Domains (2) summary
    pfam00001
    Location:60 → 312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54 → 327
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    99163353..99170519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30680.1 GenPept UniProtKB/Swiss-Prot:P30680

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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