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Rgs8 regulator of G-protein signaling 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54297, updated on 27-Nov-2024

Summary

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Official Symbol
Rgs8provided by RGD
Official Full Name
regulator of G-protein signaling 8provided by RGD
Primary source
RGD:3571
See related
EnsemblRapid:ENSRNOG00000002369 AllianceGenome:RGD:3571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and response to amphetamine. Located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and neuronal cell body membrane. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 151.5) See more
Orthologs
human mouse all
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Genomic context

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See Rgs8 in Genome Data Viewer
Location:
13q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (68355078..68399412)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65804703..65848955)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (71086654..71141820)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene S100 calcium binding protein A11, pseudogene 1 Neighboring gene regulator of G-protein signaling 16 Neighboring gene ribonuclease L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RGS8 expression in developing cerebellar Purkinje cells. Saitoh O, et al. Biochem Biophys Res Commun, 2003 Oct 3. PMID 13679049
  2. Distribution of regulator of G protein signaling 8 (RGS8) protein in the cerebellum. Saitoh O, et al. Cerebellum, 2003. PMID 12880183
  3. RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell. Itoh M, et al. Biochem Biophys Res Commun, 2001 Sep 14. PMID 11549278
  4. RGS8 accelerates G-protein-mediated modulation of K+ currents. Saitoh O, et al. Nature, 1997 Dec 4. PMID 9394004
  5. Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling. Saitoh O, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12110731, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. examination of expression of mRNA in developing cerebellum by in situ hybridization
    Title: RGS8 expression in developing cerebellar Purkinje cells.
  2. Alternative splicing determines inhibitory function of receptor type-specific Gq signaling.
    Title: Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.
  3. RGS8 protein is distributed in dendrites and cell body but not the nucleus nor axons of cerebellar Purkinje cells, suggesting protein distribution is controlled.
    Title: RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC105444

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019344.4 → NP_062217.1  regulator of G-protein signaling 8

    See identical proteins and their annotated locations for NP_062217.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P49804
    UniProtKB/TrEMBL
    A0A8I6AP34, A6ICV3
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    68355078..68399412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250015.5 → XP_006250077.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6Y1
    Related
    ENSRNOP00000073985.1, ENSRNOT00000083366.3
    Conserved Domains (1) summary
    cd08711
    Location:98 → 222
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  2. XM_039091040.2 → XP_038946968.1  regulator of G-protein signaling 8 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AP34

  3. XM_039091035.2 → XP_038946963.1  regulator of G-protein signaling 8 isoform X2

    UniProtKB/Swiss-Prot
    P49804
    UniProtKB/TrEMBL
    A0A8I6AP34, A6ICV3
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  4. XM_039091033.2 → XP_038946961.1  regulator of G-protein signaling 8 isoform X2

    UniProtKB/Swiss-Prot
    P49804
    UniProtKB/TrEMBL
    A0A8I6AP34, A6ICV3
    Related
    ENSRNOP00000090756.2, ENSRNOT00000118774.2
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  5. XM_039091037.2 → XP_038946965.1  regulator of G-protein signaling 8 isoform X2

    UniProtKB/Swiss-Prot
    P49804
    UniProtKB/TrEMBL
    A0A8I6AP34, A6ICV3
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  6. XM_039091042.2 → XP_038946970.1  regulator of G-protein signaling 8 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AP34

  7. XM_039091039.2 → XP_038946967.1  regulator of G-protein signaling 8 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AP34

  8. XM_039091036.2 → XP_038946964.1  regulator of G-protein signaling 8 isoform X2

    UniProtKB/Swiss-Prot
    P49804
    UniProtKB/TrEMBL
    A0A8I6AP34, A6ICV3
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  9. XM_006250016.5 → XP_006250078.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_006250078.1

    UniProtKB/Swiss-Prot
    P49804
    UniProtKB/TrEMBL
    A0A8I6AP34, A6ICV3
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  10. XM_039091041.2 → XP_038946969.1  regulator of G-protein signaling 8 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AP34
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49804.2 GenPept UniProtKB/Swiss-Prot:P49804

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