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Pcdh7 protocadherin 7 [ Mus musculus (house mouse) ]

Gene ID: 54216, updated on 27-Nov-2024

Summary

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Official Symbol
Pcdh7provided by MGI
Official Full Name
protocadherin 7provided by MGI
Primary source
MGI:MGI:1860487
See related
Ensembl:ENSMUSG00000029108 AllianceGenome:MGI:1860487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; ganglia; gut; sensory organ; and spinal cord mantle layer. Orthologous to human PCDH7 (protocadherin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 7.7), cortex adult (RPKM 7.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Pcdh7 in Genome Data Viewer
Location:
5 C1; 5 31.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (57873487..58290578)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (57716145..58133236)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13126 Neighboring gene synaptosomal-associated protein 23 pseudogene Neighboring gene RIKEN cDNA 4932441J04 gene Neighboring gene STARR-seq mESC enhancer starr_13127 Neighboring gene STARR-seq mESC enhancer starr_13128 Neighboring gene STARR-seq mESC enhancer starr_13129 Neighboring gene IMP1 inner mitochondrial membrane peptidase-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_13130 Neighboring gene STARR-seq mESC enhancer starr_13131 Neighboring gene STARR-seq mESC enhancer starr_13132 Neighboring gene predicted gene, 17977 Neighboring gene predicted gene, 54319 Neighboring gene STARR-seq mESC enhancer starr_13133 Neighboring gene predicted gene, 22536

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation. Kim H, et al. BMB Rep, 2020 Sep. PMID 32635982, Free PMC Article
  2. cDNA cloning and chromosomal mapping of mouse BH-protocadherin. Yoshida K, et al. DNA Seq, 1999. PMID 10565544
  3. Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice. Messing A, et al. Am J Pathol, 1998 Feb. PMID 9466565, Free PMC Article
  4. Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily. Yoshida K, et al. Genomics, 1998 May 1. PMID 9615233
  5. Overexpression of protocadherin 7 inhibits neuronal survival by downregulating BIRC5 in vitro. Xiao H, et al. Exp Cell Res, 2018 May 1. PMID 29548751

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protocadherin-7 Regulates Osteoclast Differentiation through Intracellular SET-Binding Domain-Mediated RhoA and Rac1 Activation.
    Title: Protocadherin-7 Regulates Osteoclast Differentiation through Intracellular SET-Binding Domain-Mediated RhoA and Rac1 Activation.
  2. Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation.
    Title: Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation.
  3. The existence of Pcdh7-BIRC5 signaling cascade in the cortical neurons and represent a potential therapeutic area for further investigation.
    Title: Overexpression of protocadherin 7 inhibits neuronal survival by downregulating BIRC5 in vitro.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
protocadherin-7
Names
BH-protocadherin (brain-heart)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122758.2 → NP_001116230.1  protocadherin-7 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC165316, AK039737, AK140356, AK165115
    Consensus CDS
    CCDS51505.1
    UniProtKB/TrEMBL
    A0A0A6YY83, Q3TVS7, Q3USI1
    Related
    ENSMUSP00000142319.2, ENSMUST00000191837.6
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  2. NM_001310606.1 → NP_001297535.1  protocadherin-7 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC131036, AC163275, AC165316
    Consensus CDS
    CCDS80286.1
    UniProtKB/TrEMBL
    E9Q2S0, Q3TVS7, Q3USI1
    Related
    ENSMUSP00000092376.5, ENSMUST00000094783.7
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  3. NM_001310608.1 → NP_001297537.1  protocadherin-7 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' region, which results in a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a shorter and different C-terminus, compared to isoform 1.
    Source sequence(s)
    AC165316, AK140356, AK165115, CF746345
    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  4. NM_018764.3 → NP_061234.2  protocadherin-7 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 3' coding exons and has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, compared to isoform 1.
    Source sequence(s)
    AC163275, AK140356, AK165115
    Consensus CDS
    CCDS19296.1
    UniProtKB/TrEMBL
    A2RS43, Q3TVS7, Q3USI1
    Related
    ENSMUSP00000066306.8, ENSMUST00000068110.10
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    57873487..58290578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504023.4 → XP_006504086.1  protocadherin-7 isoform X5

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  2. XM_006504019.4 → XP_006504082.1  protocadherin-7 isoform X1

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  3. XM_006504024.4 → XP_006504087.1  protocadherin-7 isoform X6

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  4. XM_006504020.4 → XP_006504083.1  protocadherin-7 isoform X2

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  5. XM_006504022.4 → XP_006504085.1  protocadherin-7 isoform X3

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  6. XM_006504029.4 → XP_006504092.1  protocadherin-7 isoform X12

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  7. XM_036165308.1 → XP_036021201.1  protocadherin-7 isoform X4

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  8. XM_006504030.4 → XP_006504093.1  protocadherin-7 isoform X13

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  9. XM_017320993.3 → XP_017176482.1  protocadherin-7 isoform X9

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  10. XM_006504025.4 → XP_006504088.1  protocadherin-7 isoform X7

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  11. XM_036165309.1 → XP_036021202.1  protocadherin-7 isoform X8

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  12. XM_006504028.4 → XP_006504091.1  protocadherin-7 isoform X10

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin

  13. XM_036165310.1 → XP_036021203.1  protocadherin-7 isoform X11

    UniProtKB/TrEMBL
    Q3TVS7, Q3USI1
    Conserved Domains (2) summary
    cd11304
    Location:541 → 635
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:842 → 1053
    Protocadherin
Nucleotide Protein Strain
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