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Ccrl2 C-C motif chemokine receptor-like 2 [ Mus musculus (house mouse) ]

Gene ID: 54199, updated on 27-Nov-2024

Summary

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Official Symbol
Ccrl2provided by MGI
Official Full Name
C-C motif chemokine receptor-like 2provided by MGI
Primary source
MGI:MGI:1920904
See related
Ensembl:ENSMUSG00000043953 AllianceGenome:MGI:1920904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E01; Ackr5; CCR11; L-CCR; Cmkbr1l2; 1810047I05Rik
Summary
Enables chemokine receptor binding activity. Involved in inflammatory response. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CCRL2 (C-C motif chemokine receptor like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 16.6), placenta adult (RPKM 10.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Ccrl2 in Genome Data Viewer
Location:
9 F2; 9 60.92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110883902..110886586, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111054834..111057518, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene receptor transporter protein 3 Neighboring gene predicted gene 10030 Neighboring gene lactotransferrin Neighboring gene STARR-seq mESC enhancer starr_25285 Neighboring gene STARR-seq mESC enhancer starr_25286 Neighboring gene ribosomal protein L31, pseudogene 19 Neighboring gene predicted gene, 26409

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway. Chen L, et al. Int Heart J, 2024. PMID 38556341
  2. Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis. Brouwer N, et al. Glia, 2004 Apr 1. PMID 14999816
  3. Nonredundant role of CCRL2 in lung dendritic cell trafficking. Otero K, et al. Blood, 2010 Oct 21. PMID 20606167, Free PMC Article
  4. Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Biber K, et al. J Leukoc Biol, 2003 Aug. PMID 12885941
  5. LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo. Zuurman MW, et al. Glia, 2003 Mar. PMID 12555200

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway.
    Title: Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway.
  2. Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
    Title: Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
  3. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
    Title: Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
  4. CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
    Title: CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
  5. The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
    Title: The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
  6. Ccrl2 modulates chemerin levels in the epithelial lining fluid of the lungs but does not contribute to the development of O3-induced lung pathology.
    Title: Chemokine (C-C Motif) Receptor-Like 2 is not essential for lung injury, lung inflammation, or airway hyperresponsiveness induced by acute exposure to ozone.
  7. upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation.
    Title: The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage.
  8. chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis.
    Title: CCRL2 regulates M1/M2 polarization during EAE recovery phase.
  9. CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 was related to the mRNA levels of F4/80, transforming growth factor beta and alpha smooth muscle actin in murine non-alcoholic steatohepatitis.
    Title: Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men.
  10. Proinflammatory stimuli upregulate atypical chemerin receptor CCRL2 and VCAM-1 on endothelial cells via NF-kappaB and JAK/STAT intracellular signaling pathways.
    Title: Expression, regulation, and function of atypical chemerin receptor CCRL2 on endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables CCR chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables chemokine receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
C-C chemokine receptor-like 2
Names
G-protein coupled beta chemokine receptor
chemokine (C-C motif) receptor-like 2
chemokine (C-C) receptor 1-like 2
chemokine receptor CCR11
lipopolysaccharide inducible C-C chemokine receptor related
lipopolysaccharide-inducible C-C chemokine receptor
lipopolysacharide-inducible C-C chemokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302376.1 → NP_001289305.1  C-C chemokine receptor-like 2

    See identical proteins and their annotated locations for NP_001289305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK007808, AK145946, BC038631, BY162594
    Consensus CDS
    CCDS23582.1
    UniProtKB/Swiss-Prot
    O35457, O70171, Q3UKM6, Q4FK04, Q91YD7
    Related
    ENSMUSP00000143116.2, ENSMUST00000199839.5
    Conserved Domains (1) summary
    cd15171
    Location:38 → 316
    7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001302377.1 → NP_001289306.1  C-C chemokine receptor-like 2

    See identical proteins and their annotated locations for NP_001289306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC118727, AK007808, AK145946, BC038631, BY162594
    Consensus CDS
    CCDS23582.1
    UniProtKB/Swiss-Prot
    O35457, O70171, Q3UKM6, Q4FK04, Q91YD7
    Conserved Domains (1) summary
    cd15171
    Location:38 → 316
    7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_017466.5 → NP_059494.2  C-C chemokine receptor-like 2

    See identical proteins and their annotated locations for NP_059494.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK007808, AK145946, BC038631
    Consensus CDS
    CCDS23582.1
    UniProtKB/Swiss-Prot
    O35457, O70171, Q3UKM6, Q4FK04, Q91YD7
    Related
    ENSMUSP00000107519.2, ENSMUST00000111888.3
    Conserved Domains (1) summary
    cd15171
    Location:38 → 316
    7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110883902..110886586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35457.2 GenPept UniProtKB/Swiss-Prot:O35457

Gene LinkOut

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