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aoc2 amine oxidase copper containing 2 [ Danio rerio (zebrafish) ]

Gene ID: 541429, updated on 9-Dec-2024

Summary

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Official Symbol
aoc2provided by ZNC
Official Full Name
amine oxidase copper containing 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-133
See related
Ensembl:ENSDARG00000014646 AllianceGenome:ZFIN:ZDB-GENE-050320-133
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
aoc3; fa94a08; fe14c05; wu:fa94a08; wu:fe14c05; zgc:113006
Summary
Predicted to enable copper ion binding activity; primary methylamine oxidase activity; and quinone binding activity. Predicted to be involved in amine metabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AOC2 (amine oxidase copper containing 2) and AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See aoc2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32924186..32927605, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (32792472..32795891, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 7a Neighboring gene glucose-6-phosphatase catalytic subunit 1b Neighboring gene NBR1 autophagy cargo receptor b Neighboring gene caspase 6b.1, apoptosis-related cysteine peptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in vitro and in vivo. Liu L, et al. Zool Res, 2020 Jul 18. PMID 32390373, Free PMC Article
  2. Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV). Wang Y, et al. Fish Shellfish Immunol, 2017 Oct. PMID 28757199
  3. Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. Nakajima H, et al. PLoS One, 2011. PMID 22046393, Free PMC Article
  4. Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. Sundström G, et al. BMC Evol Biol, 2008 Sep 19. PMID 18803835, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables primary methylamine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retina-specific copper amine oxidase
Names
amine oxidase, copper containing 3
NP_001013573.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013555.3 → NP_001013573.3  retina-specific copper amine oxidase

    Status: PROVISIONAL

    Source sequence(s)
    CT583642
    UniProtKB/TrEMBL
    A0A8M1N4I9
    Related
    ENSDARP00000121793.1, ENSDART00000140117.3
    Conserved Domains (4) summary
    PRK11504
    Location:58 → 709
    tynA; tyramine oxidase; Provisional
    pfam01179
    Location:307 → 710
    Cu_amine_oxid; Copper amine oxidase, enzyme domain
    pfam02727
    Location:61 → 144
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:194 → 258
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    32924186..32927605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395227.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    269492..272908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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