en1b engrailed homeobox 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: en1bprovided by ZNC
Official Full Name: engrailed homeobox 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-6
See related: Ensembl:ENSDARG00000098730 AllianceGenome:ZFIN:ZDB-GENE-980526-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eng4; eng1b; wu:fc84e11; zgc:113499
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Predicted to be located in nucleus. Is expressed in midbrain hindbrain boundary neural keel; myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (7679328..7683372)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (6995891..6999941)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

marks a class of inhibitory interneurons that seems to provide all of the ipsilateral glycinergic inhibition in the spinal cord of embryonic and larval fish.
Title: Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron.

Submit: New GeneRIF Correction

General gene information

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Markers

fc84e11.x1 (e-PCR)
- UniSTS:188335

fd23c06.y1 (e-PCR)
- UniSTS:195306

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis involved in innervation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein engrailed-1b

Names: engrailed 1b; engrailed 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.