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zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 [ Danio rerio (zebrafish) ]

Gene ID: 541365, updated on 4-Jan-2025

Summary

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Official Symbol
zdhhc2provided by ZNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-58
See related
Ensembl:ENSDARG00000034757 AllianceGenome:ZFIN:ZDB-GENE-050320-58
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fk53a02; zgc:110777
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including peptidyl-L-cysteine S-palmitoylation; synapse assembly; and synaptic vesicle maturation. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; postsynaptic density; and postsynaptic recycling endosome. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See zdhhc2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (30426956..30452234, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (30086642..30111796, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 7a Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene mitochondrial calcium uptake family, member 3b Neighboring gene fibroblast growth factor 20b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
  2. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC2
Names
DHHC domain-containing protein 2
acyltransferase ZDHHC2
zinc finger DHHC domain-containing protein 2
zinc finger, DHHC-type containing 2
NP_001013510.1
XP_021336686.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013492.1 → NP_001013510.1  palmitoyltransferase ZDHHC2

    See identical proteins and their annotated locations for NP_001013510.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090450
    UniProtKB/Swiss-Prot
    Q5BLG4
    Related
    ENSDARP00000019867.5, ENSDART00000011480.8
    Conserved Domains (1) summary
    cl19890
    Location:11 → 292
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    30426956..30452234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481011.2 → XP_021336686.1  palmitoyltransferase ZDHHC2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QKK4
    Conserved Domains (1) summary
    cl19890
    Location:11 → 305
    zf-DHHC; DHHC palmitoyltransferase

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394914.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    357099..381944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BLG4.1 GenPept UniProtKB/Swiss-Prot:Q5BLG4

Gene LinkOut

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