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spcs2 signal peptidase complex subunit 2 [ Danio rerio (zebrafish) ]

Gene ID: 541342, updated on 9-Dec-2024

Summary

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Official Symbol
spcs2provided by ZNC
Official Full Name
signal peptidase complex subunit 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-32
See related
Ensembl:ENSDARG00000042823 AllianceGenome:ZFIN:ZDB-GENE-050320-32
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa12g08; zgc:110364
Summary
Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of signal peptidase complex. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See spcs2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (4988185..5001388)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (4997055..5008663)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487715 Neighboring gene lipoyl(octanoyl) transferase 2 Neighboring gene ring finger protein 169 Neighboring gene defensin, beta-like 3 Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The lasting after-effects of an ancient polyploidy on the genomes of teleosts. Conant GC. PLoS One, 2020. PMID 32298330, Free PMC Article
  2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal peptidase complex subunit 2
Names
SPase 25 kDa subunit
microsomal signal peptidase 25 kDa subunit
probable signal peptidase complex subunit 2
signal peptidase complex subunit 2 homolog
NP_001013487.2
XP_068069644.1
XP_068069645.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013469.2 → NP_001013487.2  signal peptidase complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    CT027729
    UniProtKB/Swiss-Prot
    Q5BJI9
    Related
    ENSDARP00000113444.1, ENSDART00000142995.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    4988185..5001388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213544.1 → XP_068069645.1  signal peptidase complex subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q5BJI9

  2. XM_068213543.1 → XP_068069644.1  signal peptidase complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5BJI9
    Related
    ENSDARP00000062851.3, ENSDART00000062852.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJI9.1 GenPept UniProtKB/Swiss-Prot:Q5BJI9

Gene LinkOut

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