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Uevld UEV and lactate/malate dehyrogenase domains [ Mus musculus (house mouse) ]

Gene ID: 54122, updated on 4-Jan-2025

Summary

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Official Symbol
Uevldprovided by MGI
Official Full Name
UEV and lactate/malate dehyrogenase domainsprovided by MGI
Primary source
MGI:MGI:1860490
See related
Ensembl:ENSMUSG00000043262 AllianceGenome:MGI:1860490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Attp; 8430408E05Rik
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in endosome to lysosome transport. Predicted to be part of ESCRT I complex. Orthologous to human UEVLD (UEV and lactate/malate dehyrogenase domains). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 4.6), bladder adult (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uevld in Genome Data Viewer
Location:
7 B3; 7 30.63 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46572964..46608275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46923216..46958532, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene predicted gene, 39012 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene mitochondrial sheath formation associated divergent transcript Neighboring gene elongin-B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
  2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in small molecule biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 variant 3
Names
EV and lactate/malate dehydrogenase domain-containing protein
UEV-3
signaling molecule ATTP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040695.1 → NP_001035785.1  ubiquitin-conjugating enzyme E2 variant 3

    See identical proteins and their annotated locations for NP_001035785.1

    Status: VALIDATED

    Source sequence(s)
    AC090123, AK155685, CB524764
    Consensus CDS
    CCDS39965.1
    UniProtKB/Swiss-Prot
    O08761, Q3U1V6, Q7TQD3
    Related
    ENSMUSP00000091964.5, ENSMUST00000094398.13
    Conserved Domains (3) summary
    PLN02602
    Location:177 → 471
    PLN02602; lactate dehydrogenase
    pfam05743
    Location:21 → 138
    UEV; UEV domain
    cl21454
    Location:183 → 468
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46572964..46608275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540994.5 → XP_006541057.1  ubiquitin-conjugating enzyme E2 variant 3 isoform X1

    Conserved Domains (2) summary
    pfam05743
    Location:21 → 138
    UEV; UEV domain
    cl21454
    Location:183 → 359
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_006540993.5 → XP_006541056.1  ubiquitin-conjugating enzyme E2 variant 3 isoform X2

    Conserved Domains (2) summary
    pfam05743
    Location:21 → 138
    UEV; UEV domain
    cl21454
    Location:183 → 353
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_001785588.3 RNA Sequence

    Related
    ENSMUST00000207986.2

  2. XR_004934153.1 RNA Sequence

  3. XR_391352.5 RNA Sequence

  4. XR_391351.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016855.2: Suppressed sequence

    Description
    NM_016855.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1V6.1 GenPept UniProtKB/Swiss-Prot:Q3U1V6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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