Ear4 eosinophil-associated, ribonuclease A family, member 4 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ear4provided by MGI
Official Full Name: eosinophil-associated, ribonuclease A family, member 4provided by MGI
Primary source: MGI:MGI:1858238
See related: AllianceGenome:MGI:1858238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mR4; RNS2; Rnase2
Summary: Predicted to enable RNA nuclease activity and lipopolysaccharide binding activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be located in lysosome. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: not in current annotation release
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Genomic context

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Location:: 14; 14 C1

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ribonuclease A activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: non-secretory ribonuclease

Names: eosinophil cationic-type ribonuclease 4; liver, eosinophil-derived neurotoxin; murine ribonuclease 4; ribonuclease, RNase A family, 2

NP_001017422.1

EC 4.6.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017422.1 → NP_001017422.1 non-secretory ribonuclease precursor

See identical proteins and their annotated locations for NP_001017422.1

Status: VALIDATED

Source sequence(s)

AF017259

UniProtKB/Swiss-Prot

O35291

UniProtKB/TrEMBL

F6YUX7

Conserved Domains (1) summary

pfam00074
Location:31 → 152

RnaseA; Pancreatic ribonuclease