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Krt35 keratin 35 [ Mus musculus (house mouse) ]

Gene ID: 53617, updated on 27-Nov-2024

Summary

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Official Symbol
Krt35provided by MGI
Official Full Name
keratin 35provided by MGI
Primary source
MGI:MGI:1858899
See related
Ensembl:ENSMUSG00000048013 AllianceGenome:MGI:1858899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ha5; Krtha5; Krt1-24
Summary
Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in filiform papillae; skin; and tongue. Orthologous to human KRT35 (keratin 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Krt35 in Genome Data Viewer
Location:
11 D; 11 63.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99983018..99987050, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100092192..100096224, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 31 Neighboring gene predicted gene 11571 Neighboring gene keratin 32 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 36 Neighboring gene keratin 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. Gilon M, et al. Differentiation, 2008 May. PMID 18021261
  2. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Jonker L, et al. Mech Dev, 2004 Nov. PMID 15454262
  3. Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Hwang J, et al. Development, 2008 Sep. PMID 18684741, Free PMC Article
  4. Bcl11b/Ctip2 is required for development of lingual papillae in mice. Nishiguchi Y, et al. Dev Biol, 2016 Aug 1. PMID 27287879
  5. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Fleger-Weckmann A, et al. Matrix Biol, 2016 Dec. PMID 27234308

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transfected human p65 induces transcriptional activation of mouse Ha5.
    Title: Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type I cuticular Ha5
Names
K35
hair keratin acidic 5
hair keratin, type I Ha5
keratin complex 1, acidic, gene 24
keratin complex 1, gene 24
keratin, hair, acidic, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016880.2 → NP_058576.2  keratin, type I cuticular Ha5

    See identical proteins and their annotated locations for NP_058576.2

    Status: VALIDATED

    Source sequence(s)
    BC100542
    Consensus CDS
    CCDS25407.2
    UniProtKB/Swiss-Prot
    B2RU48, Q497I4, Q9Z2T8
    Related
    ENSMUSP00000099416.4, ENSMUST00000103127.4
    Conserved Domains (3) summary
    pfam00038
    Location:96 → 407
    Filament; Intermediate filament protein
    pfam16888
    Location:305 → 408
    DUF5082; Domain of unknown function (DUF5082)
    cl00459
    Location:192 → 334
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99983018..99987050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q497I4.1 GenPept UniProtKB/Swiss-Prot:Q497I4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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